Germline genetic variations in  PDZD2  and  ITPR2  genes are associated with clear cell renal cell carcinoma in Chinese population

Ning Zhang; Yishuo Wu; Jian Gong; Kaiwen Li; Xiaolin Lin; Haitao Chen; Yang Yu; Yuancheng Gou; Jiangang Hou; Deke Jiang; Rong Na; Xiang Wang; Qiang Ding; Jianfeng Xu

doi:10.18632/oncotarget.6917

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population

Ning Zhang, Yishuo Wu, Jian Gong, Kaiwen Li, Xiaolin Lin, Haitao Chen, Yang Yu, Yuancheng Gou, Jiangang Hou, Deke Jiang, Rong Na, Xiang Wang _, Qiang Ding and Jianfeng Xu

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:24196-24201. https://doi.org/10.18632/oncotarget.6917

Metrics: PDF 2503 views | HTML 2146 views | ?

Abstract

Ning Zhang1,2,*, Yishuo Wu1,2,*, Jian Gong2*, Kaiwen Li3, Xiaolin Lin2,4,5, Haitao Chen5, Yang Yu1,2, Yuancheng Gou1,2, Jiangang Hou1,2, Deke Jiang4, Rong Na1,2,6,7, Xiang Wang1,2, Qiang Ding1,2 and Jianfeng Xu2,3,4,7

1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China

2 Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China

3 Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yet-sen University, Guandong, PR China

4 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China

5 Center for Genetic Epidemiology, School of Life Sciences, Fudan University, Shanghai, PR China

6 Health Communication Institute, School of Public Health, Fudan University, Shanghai, PR China

7 Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA

* These authors have contributed equally to this work

Correspondence to:

Rong Na, email:

Xiang Wang, email:

Keywords: renal cell carcinoma, SNPs, genome-wide association, Chinese

Received: June 03, 2015 Accepted: December 31, 2015 Published: January 14, 2016

Abstract

Genome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population. All reported RCC risk-associated SNPs from GWAS were evaluated in 346 ccRCC cases and 1,130 controls. Rs10054504 (at PDZD2, Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P = 0.0006), rs718314 (at ITPR2, OR = 0.56, 95%CI:0.45-0.69, P = 5.26×10-8) and rs1049380 (at ITPR2, by dominant model, OR = 1.58, 95%CI:1.18-2.13, P = 0.0025) were significantly associated with ccRCC risk in Chinese population. To conclude, genetic variations in PDZD2 and ITPR2 are ccRCC-risk associated in Chinese population.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 6917

Publication Alerts

Research Papers:

Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population

Abstract