Research Papers:
Trop2 is overexpressed in gastric cancer and predicts poor prognosis
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Abstract
Wei Zhao1,2,*, Huijun Zhu3,*, Shu Zhang3, Hongmei Yong4, Wei Wang3, Yan Zhou5, Bing Wang5, Jinbo Wen6, Zhenning Qiu7, Guipeng Ding1, Zhenqing Feng1,7,8,9, Jin Zhu7,10
1Department of Pathology, Nanjing Medical University, Nanjing 210029, China
2School of Public Health, Nantong University, Nantong 226019, China
3Department of Pathology, Affiliated Hospital of Nantong University, Nantong 226019, China
4Department of Oncology, Huai’an Hospital Affiliated of Xuzhou Medical College and Huai’an Second People’s Hospital, Huai’an 223001, China
5Department of Oncology, AoYoung Hospital, Zhangjiagang, Jiangsu 215617, China
6Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 210029, China
7Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 210029, China
8Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 210029, China
9Key Laboratory of Cancer Biomarkers, Prevent and Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, China
10Huadong Medical Institute of Biotechniques, Nanjing 210029, China
*These authors contributed equally to this work
Correspondence to:
Zhenqing Feng, e-mail: [email protected]
Jin Zhu, e-mail: [email protected]
Keywords: Trop2, prognosis, gastric cancer
Received: August 03, 2015 Accepted: December 08, 2015 Published: December 22, 2015
ABSTRACT
The cell surface protein Trop2 is overexpressed in a variety of human cancers. Trop2 expression increases tumor development and metastasis and reduces patient survival. However, little is known about the role of Trop2 expression and its prognostic value in gastric cancer (GC), particularly in Chinese populations. We analyzed Trop2 expression in GC tissues collected from Chinese GC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry on tissue microarrays were performed to assess levels of Trop2 mRNA and protein in GC, and correlations between Trop2 expression and clinical characteristics and prognosis were analyzed. Trop2 expression was higher in GC tissues than in neighboring non-tumor tissues. Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection. GC patients with high Trop2 expression also had poor overall survival rates. These data suggest Trop2 is a useful prognostic biomarker for GC.
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