Oncotarget

Research Papers:

The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma

Rui Liu, Haiyang Zhang, Xia Wang, Likun Zhou, Hongli Li, Ting Deng, Yanjun Qu, Jingjing Duan, Ming Bai, Shaohua Ge, Tao Ning, Le Zhang, Dingzhi Huang and Yi Ba _

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Oncotarget. 2015; 6:43831-43842. https://doi.org/10.18632/oncotarget.6257

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Abstract

Rui Liu1, Haiyang Zhang1,2, Xia Wang1, Likun Zhou1, Hongli Li1, Ting Deng1, Yanjun Qu1, Jingjing Duan1, Ming Bai1, Shaohua Ge1, Tao Ning1, Le Zhang1, Dingzhi Huang1,* and Yi Ba1,*

1 Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

2 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China

Correspondence to:

Yi Ba, email:

Dingzhi Huang, email:

Keywords: Bim, miR-24, pancreatic cancer, tumorigenesis, angiogenesis

Received: June 18, 2015 Accepted: October 08, 2015 Published: October 28, 2015

Abstract

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.


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