Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

Dawei Liu; Zeeshan Shaukat; Robert B. Saint; Stephen L. Gregory

doi:10.18632/oncotarget.6035

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Research Papers: Immunology:

Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

Dawei Liu, Zeeshan Shaukat, Robert B. Saint and Stephen L. Gregory _

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Oncotarget. 2015; 6:38552-38565. https://doi.org/10.18632/oncotarget.6035

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Abstract

Dawei Liu1, Zeeshan Shaukat1, Robert B. Saint1 and Stephen L. Gregory1

1 School of Biological Sciences, University of Adelaide, Adelaide, Australia

Correspondence to:

Stephen L. Gregory, email:

Keywords: chromosomal instability, innate immune response, Drosophila, TNFα, TLRs, Immunology Section, Immunity, Immune response

Received: July 13, 2015 Accepted: September 08, 2015Published: October 08, 2015

Abstract

Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells.

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Research Papers: Immunology:

Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

Abstract