Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny

Saara Marttila _, Laura Kananen, Juulia Jylhävä, Tapio Nevalainen, Antti Hervonen, Marja Jylhä and Mikko Hurme

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Oncotarget. 2015; 6:30557-30567. https://doi.org/10.18632/oncotarget.5905

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Abstract

Saara Marttila1,2, Laura Kananen1,2, Juulia Jylhävä1,2, Tapio Nevalainen1,2, Antti Hervonen2,3, Marja Jylhä2,3,4 and Mikko Hurme1,2,5

1 Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland

2 Gerontology Research Center, Tampere, Finland

3 School of Health Sciences, University of Tampere, Tampere, Finland

4 Institute for Advanced Social Research, University of Tampere, Tampere, Finland

5 Fimlab Laboratories, Tampere, Finland

Correspondence to:

Saara Marttila, email:

Keywords: lifespan, longevity, DNA methylation, methylome, intergenerational inheritance, Gerotarget

Received: August 17, 2015 Accepted: August 27, 2015 Published: September 30, 2015

Abstract

The heritability of lifespan is 20-30%, but only a few genes associated with longevity have been identified. To explain this discrepancy, the inheritance of epigenetic features, such as DNA methylation, have been proposed to contribute to the heritability of lifespan.

We investigated whether parental lifespan is associated with DNA methylation profile in nonagenarians. A regression model, adjusted for differences in blood cell proportions, identified 659 CpG sites where the level of methylation was associated with paternal lifespan. However, no association was observed between maternal lifespan and DNA methylation. The 659 CpG sites associated with paternal lifespan were enriched outside of CpG islands and were located in genes associated with development and morphogenesis, as well as cell signaling. The largest difference in the level of methylation between the progeny of the shortest-lived and longest-lived fathers was identified for CpG sites mapping to CXXC5. In addition, the level of methylation in three Notch-genes (NOTCH1, NOTCH3 and NOTCH4) was also associated with paternal lifespan.

There are implications for the inheritance of acquired traits via epigenetic mechanisms in mammals. Here we describe DNA methylation features that are associated with paternal lifespan, and we speculate that the identified CpG sites may represent intergenerational epigenetic inheritance.


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