Rapamycin preserves gut homeostasis during  Drosophila  aging

Xiaolan Fan; Qing Liang; Ting Lian; Qi Wu; Uma Gaur; Diyan Li; Deying Yang; Xueping Mao; Zhihua Jin; Ying Li; Mingyao Yang

doi:10.18632/oncotarget.5895

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers: Gerotarget (Focus on Aging):

Rapamycin preserves gut homeostasis during Drosophila aging

Xiaolan Fan, Qing Liang, Ting Lian, Qi Wu, Uma Gaur, Diyan Li, Deying Yang, Xueping Mao, Zhihua Jin, Ying Li and Mingyao Yang _

PDF | HTML | How to cite

Oncotarget. 2015; 6:35274-35283. https://doi.org/10.18632/oncotarget.5895

Metrics: PDF 8822 views | HTML 4309 views | ?

Abstract

Xiaolan Fan1,*, Qing Liang1,*, Ting Lian1, Qi Wu1, Uma Gaur1, Diyan Li1, Deying Yang1, Xueping Mao1, Zhihua Jin2, Ying Li1 and Mingyao Yang1

1 Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, P.R. China

2 School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Zhejiang, P.R. China

* These authors have contributed equally to this work

Correspondence to:

Mingyao Yang, email:

Keywords: Drosophila, gut homeostasis, intestinal stem cell, rapamycin, aging, Gerotarget

Received: September 15, 2015 Accepted: September 22, 2015 Published: September 29, 2015

Abstract

Gut homeostasis plays an important role in maintaining the overall body health during aging. Rapamycin, a specific inhibitor of mTOR, exerts prolongevity effects in evolutionarily diverse species. However, its impact on the intestinal homeostasis remains poorly understood. Here, we demonstrate that rapamycin can slow down the proliferation rate of intestinal stem cells (ISCs) in the aging guts and induce autophagy in the intestinal epithelium in Drosophila. Rapamycin can also significantly affect the FOXO associated genes in intestine and up-regulate the negative regulators of IMD/Rel pathway, consequently delaying the microbial expansion in the aging guts. Collectively, these findings reveal that rapamycin can delay the intestinal aging by inhibiting mTOR and thus keeping stem cell proliferation in check. These results will further explain the mechanism of healthspan and lifespan extension by rapamycin in Drosophila.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 5895

Publication Alerts

Research Papers: Gerotarget (Focus on Aging):

Rapamycin preserves gut homeostasis during Drosophila aging

Abstract