Oncotarget

Research Papers: Gerotarget (Focus on Aging):

The eye lens: age-related trends and individual variations in refractive index and shape parameters

Barbara Pierscionek _, Mehdi Bahrami, Masato Hoshino, Kentaro Uesugi, Justyn Regini and Naoto Yagi

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Oncotarget. 2015; 6:30532-30544. https://doi.org/10.18632/oncotarget.5762

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Abstract

Barbara Pierscionek1, Mehdi Bahrami1, Masato Hoshino2, Kentaro Uesugi2, Justyn Regini3 and Naoto Yagi2

1 Faculty of Science, Engineering and Computing, Kingston University London, Kingston-upon-Thames, United Kingdom

2 Japan Synchrotron Radiation Research Institute (SPring-8), Sayo, Hyogo, Japan

3 School of Vision Sciences, Cardiff University, Cardiff, United Kingdom

Correspondence to:

Barbara Pierscionek, email:

Keywords: ageing, eye lens, refractive index gradients, growth, size, Gerotarget

Received: June 20, 2015 Accepted: August 26, 2015 Published: September 27, 2015

Abstract

The eye lens grows throughout life by cell accrual on its surface and can change shape to adjust the focussing power of the eye. Varying concentrations of proteins in successive cell layers create a refractive index gradient. The continued growth of the lens and age-related changes in proteins render it less able to alter shape with loss of capacity by the end of the sixth decade of life. Growth and protein ageing alter the refractive index but as accurate measurement of this parameter is difficult, the nature of such alterations remains uncertain. The most accurate method to date for measuring refractive index in intact lenses has been developed at the SPring-8 synchrotron. The technique, based on Talbot interferometry, has an X-ray source and was used to measure refractive index in sixty-six human lenses, aged from 16 to 91 years. Height and width were measured for forty-five lenses. Refractive index contours show decentration in some older lenses but individual variations mask age-related trends. Refractive index profiles along the optic axis have relatively flat central sections with distinct micro-fluctuations and a steep gradient in the cortex but do not exhibit an age-related trend. The refractive index profiles in the equatorial aspect show statistical significance with age, particularly for lenses below the age of sixty that had capacity to alter shape in vivo. The maximum refractive index in the lens centre decreases slightly with age with considerable scatter in the data and there are age-related variations in sagittal thickness and equatorial height.


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