Lymph node ratio is a prognostic factor for non-small cell lung cancer

Guangyuan Sun; Lei Xue; Mingdong Wang; Xuewei Zhao

doi:10.18632/oncotarget.5669

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Clinical Research Papers:

Lymph node ratio is a prognostic factor for non-small cell lung cancer

Guangyuan Sun, Lei Xue, Mingdong Wang and Xuewei Zhao _

PDF | HTML | How to cite

Oncotarget. 2015; 6:33912-33918. https://doi.org/10.18632/oncotarget.5669

Metrics: PDF 1391 views | HTML 1951 views | ?

Abstract

Guangyuan Sun1, Lei Xue1, Mingdong Wang1 and Xuewei Zhao1

1 Department of Thoracic and Cardiovascular Surgery, Changzheng Hospital, the Second Military Medical University, Shanghai, China

Correspondence to:

Xuewei Zhao, email:

Keywords: non-small cell lung cancer, lymph node ratio, association, meta-analysis

Received: July 09, 2015 Accepted: August 22, 2015 Published: September 15, 2015

Abstract

The lymph node ratio (LNR) is defined as the number of pathologically positive LNs divided by the number of LNs examined. Some studies reported that high LNR was significantly associated with poor survival of non-small cell lung cancer (NSCLC). However, other studies could not confirm this result. PubMed, Embase, and the Cochrane Register of Controlled Trials were searched for relevant studies published up to July 2015. Primary outcome was the relationship between LNR and disease-specific survival (DSS) and overall survival (OS). Twelve studies with 25138 NSCLC patients were included in this meta-analysis. Higher LNR was significantly associated with decreased OS (HR = 1.93; 95% CI 1.64 – 2.28; P < 0.00001) and DSS (HR = 1.82; 95% CI 1.55 – 2.14; P < 0.00001). In the subgroup analysis, N1 stage NSCLC patients with higher LNR also showed decreased OS (HR = 1.60; 95% CI 1.25 – 2.28; P = 0.0002) and DSS (HR = 1.82; 95% CI 1.55 – 2.21; P < 0.0001). This meta-analysis indicated that LNR was an independent predictor of survival in patients with NSCLC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 5669

Publication Alerts

Clinical Research Papers:

Lymph node ratio is a prognostic factor for non-small cell lung cancer

Abstract