Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines
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Jin Ho Song1,4, Ki Mun Kang1,4, Hoon-Sik Choi1, Hojin Jeong1,4, In Bong Ha1,4, Jong Deog Lee2, Ho Cheol Kim2, Yi Yeong Jeong2, Yu Ji Cho2, Seung Jun Lee2, Sung Hwan Kim3, In-Seok Jang3, Bae Kwon Jeong1,4
1Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea
2Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea
3Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea
4Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea
Bae Kwon Jeong, e-mail: firstname.lastname@example.org
Keywords: stereotactic body radiotherapy, lung cancer, calculation algorithm, CyberKnife, Monte Carlo
Received: August 10, 2015 Accepted: October 01, 2015 Published: October 26, 2015
Purpose: The purpose of this study was to compare the clinical outcomes between the groups using Ray-Tracing (RAT) and Monte-Carlo (MC) calculation algorithms for stereotactic body radiotherapy (SBRT) of lung tumors.
Materials and Methods: Thirty-five patients received SBRT with CyberKnife for 47 primary or metastatic lung tumors. RAT was used for 22 targets in 12 patients, and MC for 25 targets in 23 patients. Total dose of 48 to 60 Gy was prescribed in 3 to 5 fractions on median 80% isodose line. The response rate, local control rate, and toxicities were compared between RAT and MC groups.
Results: The response rate was lower in the RAT group (77.3%) compared to the MC group (100%) (p = 0.008). The response rates showed an association with the mean dose to the gross tumor volume, which the doses were re-calculated with MC algorithm in both groups. However, the local control rate and toxicities did not differ between the groups.
Conclusions: The clinical outcome and toxicity of lung SBRT between the RAT and MC groups were similar except for the response rate when the same apparent doses were prescribed. The lower response rate in the RAT group, however, did not compromise the local control rates. As such, reducing the prescription dose for MC algorithm may be performed but done with caution.
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