Molecular pathological epidemiology of colorectal cancer in Chinese patients with  KRAS  and  BRAF  mutations

Wenbin Li; Tian Qiu; Yun Ling; Lei Guo; Lin Li; Jianming Ying

doi:10.18632/oncotarget.5551

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Molecular pathological epidemiology of colorectal cancer in Chinese patients with KRAS and BRAF mutations

Wenbin Li _, Tian Qiu, Yun Ling, Lei Guo, Lin Li and Jianming Ying

PDF | HTML | How to cite

Oncotarget. 2015; 6:39607-39613. https://doi.org/10.18632/oncotarget.5551

Metrics: PDF 2313 views | HTML 2801 views | ?

Abstract

Wenbin Li1, Tian Qiu1, Yun Ling1, Lei Guo1, Lin Li1, Jianming Ying1

1Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Correspondence to:

Jianming Ying, e-mail: [email protected]

Keywords: colorectal cancer, KRAS, BRAF, mutation, molecular pathological epidemiology

Received: July 27, 2015 Accepted: October 09, 2015 Published: October 22, 2015

ABSTRACT

An investigation of interactive effects of exogenous and endogenous factors and tumor molecular changes can lead to a better understanding of tumor molecular signatures in colorectal cancer. We here report a molecular pathological epidemiology study in a large cohort of 945 colorectal cancer patients. Mutations of KRAS (36.6%) and BRAF (3.46%) were nearly mutually exclusive. KRAS-mutated tumors were more common in female patients (odds ratio [OR] = 1.68; P = 0.0001) and never smokers (OR = 1.60; P = 0.001). Whereas BRAF-mutated tumors demonstrated no discrepancy in aspects of gender and smoking status compared with wild-type tumors. In addition, tumors with BRAF or KRAS mutations were in correlation with elevated serum level of carbohydrate antigen (CA19-9) and carcinoma embryonic antigen (CEA) and the combination of serum biomarkers and molecular mutation status may enhance the more precise risk stratification of CRC patients. Further studies are needed to define the mechanism brought about by the aforementioned epidemiologic and clinicopathologic characteristics that may help optimize cancer prevention and precision therapy.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 5551

Publication Alerts

Research Papers:

Molecular pathological epidemiology of colorectal cancer in Chinese patients with KRAS and BRAF mutations

Abstract