Oncotarget

Clinical Research Papers:

The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma

Guang-Zhi Jin _, Wei Dong, Hui Dong, Hua Yu, Jia Chen, Wen-Long Yu, Ai-Jun Li, Wen-Ming Cong and Meng-Chao Wu

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Oncotarget. 2015; 6:39357-39364. https://doi.org/10.18632/oncotarget.5329

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Abstract

Guang-Zhi Jin1,*, Wei Dong1,*, Hui Dong1,*, Hua Yu1,*, Jia Chen1, Wen-Long Yu2,**, Ai-Jun Li3,**, Wen-Ming Cong1,**, Meng-Chao Wu4

1Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

2Department II of Biliary Tract Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

3Division of Special Treatment II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

4Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

*These authors contributed equally to this work

**Senior authors contributed equally to this work.

Correspondence to:

Wen-Ming Cong, e-mail: wmcong@smmu.edu.cn

Ai-Jun Li, e-mail: ajli@smmu.edu.cn

Wen-Long Yu, e-mail: yu_wenlong@sina.cn

Keywords: myeloid-related protein 8, myeloid-related protein 14, tumor-infiltrating immune cell, intrahepatic cholangiocarcinoma, prognosis

Received: May 06, 2015     Accepted: October 02, 2015     Published: October 12, 2015

ABSTRACT

Myeloid-related protein 8 (MRP8) and 14 (MRP14) are abundantly expressed in several kinds of benign and malignant tumors. However, little is known about their clinicopathological significance in intrahepatic cholangiocarcinoma (ICC), biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of bile duct (IPNB), or inflammatory hepatic biliary ducts epithelium (IHBD). This study aimed to investigate the diagnostic and prognostic values of MRP8 and MRP14 as new biomarkers for ICC. We examined MRP8 and MRP14 expression levels by immunohistochemistry in IHBD (n = 15), BilIN (BilIN1 = 24, BilIN2 = 9, BilIN3 = 5), IPNB (n = 18) and ICC (n = 416). The differential diagnostic and prognosis values were also evaluated. The results showed that the ratio of tumor-infiltrating MRP8 and MRP14 positive immune cells, relative to biliary epithelial cells, was significantly increased in ICC tissues compared with nonmalignant tissues, including IHBD, BilIN1, BilIN2, BilIN3, and IPNB (P value < 0.05). In addition, over-expression levels of MRP8 and MRP14 were correlated with overall survival (OS) and time to recurrence (TTR) by univariate analysis; MRP8/MRP14 combination was an independent prognostic factor for OS and TTR. MRP8 and MRP14 expression might help to identify the benign bile duct diseases from ICC, as high expression of MRP8 and MRP14 suggests a poor prognosis after surgical resection.


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