Oncotarget

Clinical Research Papers:

A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer

Chengyuan Gu, Yuanyuan Qu, Guiming Zhang, LiJiang Sun, Yao Zhu and Dingwei Ye _

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Oncotarget. 2015; 6:32205-32211. https://doi.org/10.18632/oncotarget.4980

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Abstract

Chengyuan Gu1,2,*, Yuanyuan Qu1,2,*, Guiming Zhang1,2,3, LiJiang Sun3, Yao Zhu1,2 and Dingwei Ye1,2

1 Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China

2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

3 Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China

* These authors have contributed equally to this work

Correspondence to:

Yao Zhu, email:

Dingwei Ye, email:

Keywords: biochemical recurrence; adiponectin; prostate cancer; radical prostatectomy; single-nucleotide polymorphism

Received: May 05, 2015 Accepted: July 16, 2015 Published: July 22, 2015

Abstract

Adiponectin has been implicated in prostate cancer (PCa) aggressiveness. However, the role of genetic variations in the adiponectin (ADIPOQ) gene in PCa progression remains unknown. To determine whether genetic variants in ADIPOQ are associated with the risk of biochemical recurrence (BCR) after radical prostatectomy (RP). We evaluated three common ADIPOQ polymorphisms in 728 men with clinically localized PCa who underwent RP. Multivariable Cox proportional hazards models and Kaplan–Meier analysis were used to assess their prognostic significance on BCR. The plasma adiponectin concentrations were measured by enzyme-linked immunosorbent assay. ADIPOQ rs182052 variant allele was associated with both increased risk of BCR [HR: 2.44; 95% confidence interval (CI): 1.57–;3.79, P = 6×10-5] and decreased adiponectin level (β = -0.048, P = 0.004). Stratified analyses demonstrated that the association was more pronounced in men with higher visceral adipose tissue. Our data support that the ADIPOQ rs182052 SNP may be a predictive biomarker for BCR after RP by a possible mechanism of altering the adiponectin level. If validated, genetic predictors of outcome may help individualizing treatment for PCa.


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