MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
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Tao Yu1,*, Lei Liu1,*, Jing Li1, Mingxia Yan1, Hechun Lin1, Ying Liu1, Dandan Chu1, Hong Tu1, Aiqin Gu2 and Ming Yao1
1 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2 Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
* Authors share co-first authorship
Ming Yao, email:
Aiqin Gu, email:
Keywords: NSCLC, metastasis, microRNA-10a, PTEN
Received: April 15, 2015 Accepted: July 11, 2015 Published: July 22, 2015
MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.
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