Oncotarget

Research Papers:

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

Tao Yu, Lei Liu, Jing Li, Mingxia Yan, Hechun Lin, Ying Liu, Dandan Chu, Hong Tu, Aiqin Gu and Ming Yao _

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Oncotarget. 2015; 6:30239-30250. https://doi.org/10.18632/oncotarget.4972

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Abstract

Tao Yu1,*, Lei Liu1,*, Jing Li1, Mingxia Yan1, Hechun Lin1, Ying Liu1, Dandan Chu1, Hong Tu1, Aiqin Gu2 and Ming Yao1

1 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2 Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

* Authors share co-first authorship

Correspondence to:

Ming Yao, email:

Aiqin Gu, email:

Keywords: NSCLC, metastasis, microRNA-10a, PTEN

Received: April 15, 2015 Accepted: July 11, 2015 Published: July 22, 2015

Abstract

MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.


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