Oncotarget

Research Papers:

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

Shixian Lian, Yebo Shao, Houbao Liu, Junyi He, Weiqi Lu, Yong Zhang, Ying Jiang and Jun Zhu _

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Oncotarget. 2015; 6:29076-29086. https://doi.org/10.18632/oncotarget.4931

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Abstract

Shixian Lian1,*, Yebo Shao1,*, Houbao Liu1,*, Junyi He1,*, Weiqi Lu1, Yong Zhang1, Ying Jiang1, Jun Zhu1

1Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China

*These authors have contributed equally to this work

Correspondence to:

Zhu J., e-mail: zhujun1024@126.com

Keywords: 3-phosphoinositide-dependent protein kinase 1, JunB, invasion, migration, epithelial–mesenchymal transition

Received: April 20, 2015     Accepted: July 23, 2015     Published: August 05, 2015

ABSTRACT

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial–mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.


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