Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

Fei Wang, Xueyan Shen, Shuping Li, Long Chen, Yanru Wang, Jie Qin, Guomin Zhou, Yuwen Peng, Xiaoyuan Feng, Ruixi Li and Chunmin Liang _

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Oncotarget. 2015; 6:20851-20862. https://doi.org/10.18632/oncotarget.4930

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Abstract

Fei Wang1,*, Xueyan Shen1,*, Shuping Li2,3,*, Long Chen1, Yanru Wang1, Jie Qin1, Guomin Zhou1, Yuwen Peng1, Xiaoyuan Feng2, Ruixi Li1, Chunmin Liang1

1Department of Anatomy and Histology & Embryology, Shanghai Medical College of Fudan University, Shanghai, P. R. China

2Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P. R. China

3Department of Radiology, PLA No.455 Hospital, Shanghai, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Chunmin Liang, e-mail: cmliang@fudan.edu.cn

Keywords: Gerotarget, Alzheimer’s disease, splenocytes, immunosenescence, GDF11, Treg

Received: June 25, 2015     Accepted: July 24, 2015     Published: August 06, 2015

ABSTRACT

Immunosenescence contributes to pathogenesis of Alzheimer's disease (AD) in the elderly. In this study, we explored the effects of young wild type (WT) splenocytes (ySCs) on Alzheimer's disease by transplanting ySCs into APPswe/PSENldE9 transgenic mice. Young WT splenocytes not only prevented AD, but also improved the spatial learning and memory of APPswe/PSENldE9 transgenic mice. Young WT splenocytes enhanced Aβ clearance, decreased astrogliosis and increased systemic growth differentiation factor 11 (GDF11) levels. Splenocytes derived from old AD mouse promoted AD. There was an increased number of regulatory T cells (Tregs) among old AD splenocytes. We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.


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