SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

Gang Deng; Lei Zhu; Feizhou Huang; Wanpin Nie; Wei Huang; Hongbo Xu; Shaopeng Zheng; Zhongjie Yi; Tao Wan

doi:10.18632/oncotarget.4862

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

Gang Deng, Lei Zhu, Feizhou Huang _, Wanpin Nie, Wei Huang, Hongbo Xu, Shaopeng Zheng, Zhongjie Yi and Tao Wan

PDF | HTML | How to cite

Oncotarget. 2015; 6:27416-27426. https://doi.org/10.18632/oncotarget.4862

Metrics: PDF 1880 views | HTML 2166 views | ?

Abstract

Gang Deng1, Lei Zhu1, Feizhou Huang1, Wanpin Nie1, Wei Huang1, Hongbo Xu1, Shaopeng Zheng1, Zhongjie Yi1, Tao Wan1

1Department of Hepatobiliary and Pancreatic Surgery, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China

Correspondence to:

Feizhou Huang, e-mail: [email protected]

Keywords: intrahepatic cholangiocarcinoma, SALL4, proliferation, migration, invasion

Received: May 07, 2015 Accepted: July 27, 2015 Published: August 07, 2015

ABSTRACT

Intrahepatic cholangiocarcinoma (ICC) is the most common and deadly disease of the biliary tree due to its poor prognosis. Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC). In our study, 175 ICC cases with an average age of 55 years were included, and 53% (93/175) were male. And 28 adjacent non-tumor tissues were also collected. The SALL4-positive immunoreactivity was detected in a total of 102 ICC cases (58%), whereas all 28 adjacent tissues showed negative staining. Univariate analysis, showed that the SALL4-positive ICC cases had significantly more frequent lymph nodal metastasis (P = 0.0460), vascular invasion (P < 0.0001), and nerve invasion (P < 0.0001). Furthermore, the strong SALL4-positive cases (n = 7, 5 months) had shorter overall survival, when compared to moderate SALL4-positive (n = 46, 9 months) or SALL4-negative cases (n = 73, 7 months), respectively. Our data also suggest that SALL4 may be involved in the regulation of epithelial-mesenchymal transition (EMT) in ICC. Those results for the first time indicate an oncogenic role of SALL4 in ICC. Therefore, SALL4 may serve as a promising therapeutic target for ICC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 4862

Publication Alerts

Research Papers:

SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

Abstract