Oncotarget

Research Papers:

SIRT1 in B[a]P-induced lung tumorigenesis

Jianyi Lu _, Min Zhang, Zhiyong Huang, Sufang Sun, Yongliang Zhang, Lei Zhang, Lirong Peng, Ailing Ma, Pan Ji, Jia Dai, Tong Cui, Heping Liu and Jimin Gao

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Oncotarget. 2015; 6:27113-27129. https://doi.org/10.18632/oncotarget.4729

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Abstract

Jianyi Lu1,*, Min Zhang1,*, Zhiyong Huang2,*, Sufang Sun1, Yongliang Zhang1, Lei Zhang1, Lirong Peng1, Ailing Ma1, Pan Ji1, Jia Dai1, Tong Cui1, Heping Liu1, Jimin Gao1

1Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China

2Department of Cardiothoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China

*These authors have contributed equally to this work

Correspondence to:

Jimin Gao, e-mail: jimingao@yahoo.com

Heping Liu, e-mail: hl691296@hotmail.com

Keywords: B[a]P, SIRT1, TNF-α, β-catenin, lung cancer

Received: February 04, 2015     Accepted: July 16, 2015     Published: July 28, 2015

ABSTRACT

Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]P induced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressed in the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1 up-regulated TNF-α and β-catenin and down-regulated the membrane fraction of E-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesis of BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-α/β-catenin axis and is as a potential therapeutic target for lung cancer.


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