Oncotarget

Reviews:

The emerging role of CaMKII in cancer

Yan-yang Wang, Ren Zhao and Hong Zhe _

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Oncotarget. 2015; 6:11725-11734. https://doi.org/10.18632/oncotarget.3955

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Abstract

Yan-yang Wang1,2, Ren Zhao1,2 and Hong Zhe1,2

1 Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

2 Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia, China

Correspondence to:

Hong Zhe, email:

Keywords: Ca2+/calmodulin-dependent protein kinase II (CaMKII), cancer, cell cycle, therapeutic target, CaMKII inhibitor

Received: January 10, 2015 Accepted: April 08, 2015 Published: April 29, 2015

Abstract

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of CaMKII in the regulation of cancer progression and therapy response. We also describe the role of CaMKII in the diagnosis of different kinds of cancer and recent progress in the development of CaMKII inhibitors. These data establishes CaMKII as a novel target whose modulation presents new opportunities for cancer diagnosis and treatment.


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