Oncotarget

Priority Research Papers:

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression

Taewan Kim _, Ri Cui, Young-Jun Jeon, Paolo Fadda, Hansjuerg Alder, Carlo M. Croce

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Oncotarget. 2015; 6:18780-18789. https://doi.org/10.18632/oncotarget.3909

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Abstract

Taewan Kim1,*, Ri Cui2,*, Young-Jun Jeon2, Paolo Fadda2, Hansjuerg Alder2, Carlo M. Croce2

1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

2Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

*These authors have contributed equally to this work

Correspondence to:

Carlo M. Croce, e-mail: carlo.croce@osumc.edu

Keywords: MYC, long noncoding RNA, cell proliferation, cell cycle

Received: April 09, 2015     Accepted: April 28, 2015     Published: May 11, 2015

ABSTRACT

The transcription factor MYC is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. The recent identification of MYC-regulated long noncoding RNAs (lncRNAs) expands our knowledge of the role of lncRNAs in MYC functions. Here, we identify MYC-repressed lncRNAs named MYCLo-4, -5 and -6 by comparing 3 categories of lncRNAs (downregulated in highly MYC-expressing colorectal cancer, up-regulated by MYC knockdown in HCT116, upregulated by MYC knockdown in RKO). The MYC-repressed MYCLos are implicated in MYC-modulated cell proliferation through cell cycle regulation. By screening cell cycle-related genes regulated by MYC and the MYC-repressed MYCLos, we identified the MYC-repressed gene GADD45A as a target gene of the MYC-repressed MYCLos such as MYCLo-4 and MYCLo-6.


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