Oncotarget

Clinical Research Papers:

Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US

Dan-Na Chen, Chuan-Gui Song _, Qian-Wen Ouyang, Yi-Zhou Jiang, Fu-Gui Ye, Fang-Jing Ma, Rong-Cheng Luo and Zhi-Ming Shao

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Oncotarget. 2015; 6:12774-12782. https://doi.org/10.18632/oncotarget.3666

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Abstract

Dan-Na Chen1,*, Chuan-Gui Song1,*, Qian-Wen Ouyang2,3,*, Yi-Zhou Jiang4,*, Fu-Gui Ye1, Fang-Jing Ma4, Rong-Cheng Luo2, Zhi-Ming Shao4

1 Department of Breast Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China

2 Cancer Center, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, China

3 Department of Breast Surgery, The Third Hospital of Nanchang, Nanchang, China

4 Department of Breast Surgery, Key Laboratory of Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China

* These authors have contributed equally to this work.

Correspondence to:

Yi-Zhou Jiang, email:

Chuan-Gui Song, email:

Rong-Cheng Luo, email:

Keywords: breast cancer, clinicopathological characteristics, prognosis, Chinese, Caucasian

Received: February 06, 2015 Accepted: February 28, 2015 Published: March 26, 2015

Abstract

Chinese breast cancer patients living in the United States (US) can experience different disease patterns than Caucasians, which might allow for predicting the future epidemiology of breast cancer in China. We aimed to compare the clinicopathologic characteristics and outcomes of Caucasian and Chinese female breast cancer patients residing in the US. The study cohort consisted of 3868 Chinese and 208621 Caucasian women (diagnosed from 1990 to 2009) in the US Surveillance, Epidemiology, and End Results (SEER) database. Compared with the Caucasian patients, the US-residing Chinese patients had a younger age at diagnosis and a higher family income, remained married longer, and more frequently lived in metropolitan areas. Other tumor characteristics were similarly distributed between the two races. Compared with the Caucasians, the Chinese patients had a significantly improved overall survival (OS) but similar breast cancer-specific survival (BCSS). Our analysis suggested that US-residing Chinese patients had significant differences in age, family income, marital status and area of residence, compared with their Caucasian counterparts. No significant disparities were noted in BCSS between the two races, whereas the Chinese patients had a significantly better OS. These findings warrant further investigation and should be considered in the screening and treatment of breast cancer.


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