Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Sheng Zhang; Jie Li; Pingguo Liu; Jianfeng Xu; Wenxiu Zhao; Chengrong Xie; Zhenyu Yin; Xiaomin Wang

doi:10.18632/oncotarget.3570

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Research Papers:

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Sheng Zhang, Jie Li, Pingguo Liu, Jianfeng Xu, Wenxiu Zhao, Chengrong Xie, Zhenyu Yin and Xiaomin Wang _

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Oncotarget. 2015; 6:11074-11086. https://doi.org/10.18632/oncotarget.3570

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Abstract

Sheng Zhang1,*, Jie Li1,*, Pingguo Liu1, Jianfeng Xu1, Wenxiu Zhao1, Chengrong Xie1, Zhenyu Yin1 and Xiaomin Wang1

1 Department of Hepatobiliary Surgery, Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma (Xiamen University Affiliated ZhongShan Hospital), Xiamen, Fujian China

* These authors contributed equally to this work

Correspondence to:

Xiaomin Wang, email:

Zhenyu Yin, email:

Keywords: pygopus-2, E-cadherin, hepatic carcinoma, invasion, metastasis

Received: January 26, 2015 Accepted: February 22, 2015 Published: March 14, 2015

Abstract

Pygopus-2 over-expression has been reported in several malignancies, such as ovarian, breast, lung and liver cancers. Here we demonstrated that down-regulation of Pygopus-2 by shRNA inhibited hepatic carcinoma cell invasion in vitro and metastasis in xenograft tumor models, which were promoted when Pygopus-2 was over-expressed. Pygopus-2 increased hepatic carcinoma cell invasion and metastasis, by decreasing E-cadherin. Pygopus-2 could bind to the E-cadherin promoter, increasing its methylation, and also indirectly decreased zeb2 expression. In turn these effects caused down-regulation of E-cadherin, potentiating invasion and metastasis. We suggest that targeting Pygopus-2 may potentially inhibit metastasis of hepatic carcinoma.

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Research Papers:

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Abstract