Oncotarget

Research Perspectives:

ARID2: A new tumor suppressor gene in hepatocellular carcinoma

Hong Zhao, Jian wang, Yongqing Han, Zhen Huang, Jianming Ying, Xinyu Bi, Jianjun Zhao, Yi Fang, Haitao Zhou, Jianguo Zhou, Zhiyu Li, Yefan Zhang, Xue Yang, Tao Yan, Linfang Wang, Michael S Torbenson and Jianqiang Cai _

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Oncotarget. 2011; 2:886-891. https://doi.org/10.18632/oncotarget.355

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Abstract

Hong Zhao1,5, Jian Wang1,5, Yongqing Han2,5, Zhen Huang1, Jianming Ying3, Xinyu Bi1, Jianjun Zhao1, Yi Fang1, Haitao Zhou1, Jianguo Zhou1, Zhiyu Li1, Yefan Zhang1, Xue Yang1, Tao Yan1 , Linfang Wang2, Michael S. Torbenson4, Jianqiang Cai1

1 Department of abdominal surgical oncology , Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P.R. China

2 National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, P.R. China

3 Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P.R. China

4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

5 These authors contributed equally to this work

* These authors contributed equally to the work

Received: November 15, 2011; Accepted: November 16, 2011; Published: November 16, 2011;

Keywords: Hepatocellular Carcinoma, Hepatitis C Virus, ARID2, Tumor Suppressor, Interferon

Correspondence:

Jianqiang Cai, email:

Linfang Wang, email:

Michael S. Torbenson, email:

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, however, genetic-environmental interactions and mechanisms associated with the development of HCC remains largely unclear. Our recent work described novel inactivating mutations of ARID2 (AT-rich interactive domain 2) in four major subtypes of HCC through exomic sequencing of ten HCV-associated HCCs and subsequent evaluation of the tumors from additional affected individuals. Here, we summarize the current knowledge about the relevance of ARID2 in HCC and the implication in future patient care.


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