Oncotarget

Clinical Research Papers:

Prognostic value of monocyte and neutrophils to lymphocytes ratio in patients with metastatic soft tissue sarcoma

Long Jiang _, Shanshan Jiang, Dongrong Situ, Yongbin Lin, Han Yang, Yuanfang Li, Hao Long and Zhiwei Zhou

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Oncotarget. 2015; 6:9542-9550. https://doi.org/10.18632/oncotarget.3283

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Abstract

Long Jiang1,2,3,4,*, Shanshan Jiang1,2,3,*, Dongrong Situ1,2,3,*, Yongbin Lin1,2,3, Han Yang1,2,3, Yuanfang Li1,2,3, Hao Long1,2,3, Zhiwei Zhou1,2,3

1Sun Yat-sen University Cancer Center, Guangzhou, China

2Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

3State Key Laboratory of Oncology in South China, Guangzhou, China

4University of California, San Francisco, CA, USA

*These authors have contributed equally to this work

Correspondence to:

Zhiwei Zhou, e-mail: zhouzhw@sysucc.org.cn

Hao Long, e-mail: longhao@sysucc.org.cn

Keywords: soft tissue sarcoma, metastasis, immunity, prognosis

Received: December 23, 2014     Accepted: February 05, 2015     Published: March 20, 2015

ABSTRACT

Metastatic soft tissue sarcomas (STS) represent enormous challenges to improve the low survival rate, which is almost the same as past 2 decades ago. Prognosis of cancer patients are based not only on tumor-related factors but also on host-related factors, particularly systemic inflammatory response. We evaluated the association among possible risk factors and survival for metastatic STS by reviewed a single-institution nearly 50-year experience. We found that both monocyte ratio and NLR ratio were significant prognostic predictors for OS and PFS of metastatic STS. And patients with monocyte ratio or NLR ratio > 1 should be screened out as candidates for more intensive or aggressive multimodality treatments and more aggressive follow-up. For this reason, this result could serve as a basis for future prospective study.


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