Targeting cancer with peptide aptamers
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1Heat Shock Proteins and Cancer, INSERM, UMR 866 IFR 100, Faculty of Medicine, 7 Boulevard Jeanne D'Arc, 21000 Dijon, France
2Université de Bourgogne, Dijon, France
3CNRS USR 3151, P2I2 Group, Station Biologique, Roscoff, Bretagne, France
Received: June 22, 2011; Accepted: June 24, 2011; Published: June 24, 2011;
Renaud Seigneuric, email:
A major endeavour in cancer chemotherapy is to develop agents that specifically target a biomolecule of interest. There are two main classes of targeting agents: small molecules and biologics. Among biologics (e.g.: antibodies), DNA, RNA but also peptide aptamers are relatively recent agents. Peptide aptamers are seldom described but represent attractive agents that can inhibit a growing panel of oncotargets including Heat Shock Proteins. Potential pitfalls and coming challenges towards successful clinical trials are presented such as optimizing the delivery of peptide aptamers thanks to Nanotechnology.
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