Axl signaling is an important mediator of tumor angiogenesis
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Mai Tanaka1 and Dietmar W. Siemann1
1 Department of Radiation Oncology, College of Medicine, University of Florida, Gainesville, FL, USA
Keywords: Axl; angiogenesis; cancer metastasis; BGB324; receptor tyrosine kinase
Received: March 10, 2019 Accepted: April 08, 2019 Published: April 23, 2019
The growth of primary tumors as well as metastatic neoplastic lesions is strongly dependent on the cancer cells’ ability to initiate their own vascular network. This process, angiogenesis, which involves the proliferation, migration, and invasion of endothelial cells, is critically dependent on a variety of signaling molecules that target specific receptors, most notably tyrosine kinases. One receptor tyrosine kinase associated with poor prognosis, metastasis, and outcome in a variety of tumor types, is Axl. Although the role of Axl in tumor cell migration and invasion are well recognized, little is known about the involvement of Axl signaling in the initiation of angiogenesis. Here, we show that Axl inhibition in tumor cells decreases the secretion of pro-angiogenic factors and impairs functional properties of endothelial cells in vitro and in vivo. These data indicate that Axl signaling is an important contributor to tumor angiogenesis.
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