MEF-2 isoforms’ (A-D) roles in development and tumorigenesis

Kiran Madugula; Ria Mulherkar; Zafar K. Khan; DeGaulle I. Chigbu; Dip Patel; Edward W. Harhaj; Pooja Jain

doi:10.18632/oncotarget.26763

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MEF-2 isoforms’ (A-D) roles in development and tumorigenesis

Kiran Madugula, Ria Mulherkar, Zafar K. Khan, DeGaulle I. Chigbu, Dip Patel, Edward W. Harhaj and Pooja Jain _

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Oncotarget. 2019; 10:2755-2787. https://doi.org/10.18632/oncotarget.26763

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Abstract

Kiran Madugula1, Ria Mulherkar1, Zafar K. Khan1, DeGaulle I. Chigbu1, Dip Patel1, Edward W. Harhaj2 and Pooja Jain1

1Department of Microbiology and Immunology, the Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19129, USA

2Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA 17033, USA

Correspondence to:

Pooja Jain, email: [email protected]

Keywords: MEF-2; HDACs; HDACi; HTLV-1; ATLL

Received: November 26, 2018 Accepted: February 01, 2019 Published: April 12, 2019

ABSTRACT

Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner. Four isoforms of MEF-2 (A-D) differentially participate in controlling the cell fate during the developmental phases of cardiac, muscle, vascular, immune and skeletal systems. Through their associations with various cellular factors MEF-2 isoforms can trigger alterations in complex protein networks and modulate various stages of cellular differentiation, proliferation, survival and apoptosis. The role of the MEF-2 family of transcription factors in the development has been investigated in various cell types, and the evolving alterations in this family of transcription factors have resulted in a diverse and wide spectrum of disease phenotypes, ranging from cancer to infection. This review provides a comprehensive account on MEF-2 isoforms (A-D) from their respective localization, signaling, role in development and tumorigenesis as well as their association with histone deacetylases (HDACs), which can be exploited for therapeutic intervention.

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MEF-2 isoforms’ (A-D) roles in development and tumorigenesis

Abstract