CD248: A therapeutic target in cancer and fibrotic diseases

Beverly A. Teicher

doi:10.18632/oncotarget.26590

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CD248: A therapeutic target in cancer and fibrotic diseases

Beverly A. Teicher _

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Oncotarget. 2019; 10:993-1009. https://doi.org/10.18632/oncotarget.26590

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Abstract

Beverly A. Teicher1

1Molecular Pharmacology Branch, Developmental Therapeutics Program, DCTD, National Cancer Institute, Bethesda 20892, MD, USA

Correspondence to:

Beverly A. Teicher, email: [email protected] [email protected]

Keywords: CD248; endosialin; TEM1; sarcoma; fibrotic disease

Received: November 29, 2018 Accepted: December 22, 2018 Published: January 29, 2019

ABSTRACT

CD248/endosialin/TEM1 is a type 1 transmembrane glycoprotein found on the plasma membrane of activated mesenchymal cells. CD248 functions during embryo development and is either not expressed or found at very low levels in adult tissues. CD248 is expressed at high levels by malignant sarcoma cells, by the pericyte component of tumor vasculature and by mesenchymal cells in some fibrotic diseases. CD248 is being targeted by several experimental therapeutics including antibodies, antibody drug conjugates, as an antigen for CART cells and in therapeutic vaccines. Although the function of CD248 has yet to be fully elucidated, this protein is a potential broad scope therapeutic target.

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CD248: A therapeutic target in cancer and fibrotic diseases

Abstract