Oncotarget

Research Papers:

A single-center experience of post-transplant lymphomas involving the central nervous system with a review of current literature

Anju John John Velvet _, Shiv Bhutani, Stavros Papachristos, Reena Dwivedi, Michael Picton, Titus Augustine, Muir Morton

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Oncotarget. 2019; 10:437-448. https://doi.org/10.18632/oncotarget.26522

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Abstract

Anju John John Velvet2, Shiv Bhutani1, Stavros Papachristos2, Reena Dwivedi4, Michael Picton1, Titus Augustine2,3 and Muir Morton1

1Department of Renal Medicine and Transplant Nephrology, Manchester Royal Infirmary, Manchester University Hospitals NHS Foundation Trust, Manchester, UK

2Department of Renal and Pancreas Transplantation, Division of Surgery, Manchester Royal Infirmary, Manchester University Hospitals NHS Foundation Trust, Manchester, UK

3Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

4Department of Radiology, Manchester Royal Infirmary, Manchester University Hospitals NHS Foundation Trust, Manchester, UK

Correspondence to:

Anju John John Velvet, email: anjujohn198924@gmail.com

Keywords: CNS-PTLD; EBV; mycophenolate; transplantation; immunosuppression

Received: May 14, 2018     Accepted: December 13, 2018     Published: January 11, 2019

ABSTRACT

Background: Central Nervous System (CNS) lymphoma is a rare presentation of post-transplantation lymphoproliferative disorder (PTLD).

Methods: This single center retrospective study reviewed presentations, management and outcomes of CNS lymphomas in kidney transplant patients transplanted 1968 to 2015, and reviews relevant current literature.

Results: We identified 5773 adult kidney transplant recipients of who 90 had a PTLD diagnosis confirmed. CNS disease was diagnosed in 6/90 (7%). Median age at presentation was 60 years and time from transplant 4.5 years. Immunosuppression at diagnosis included mycophenolate mofetil and prednisolone without calcineurin inhibitor in 5/6 patients. Histological analysis diagnosed monomorphic disease in 5/6, and one polymorphic case with tissue positive for Epstein-barr virus (EBV) in 5/6 cases. Despite this 2/4 EBV positive cases had no detectable EBV in peripheral blood or CSF at diagnosis. Treatment strategies included reduction in immunosuppression in all, chemotherapy (n=5), radiotherapy (n=3), Cytotoxic T-Lymphocytes and Craniotomy (n=2). Patient survival was 40% at 1 year with CTL treated patients surviving beyond three years from diagnosis.

Conclusion: This study supports observational data suggesting MMF treated patients without CNI may have increased risk of disease. Peripheral blood screening for EBV DNAemia does not seem helpful in early identification of those at risk.


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