Oncotarget

Research Papers:

Brief report on similar mutational changes in neurofibromatosis type 2 gene in minute pulmonary meningothelial-like nodule and meningioma of the central nervous system

Mitsunori Higuchi _, Masayuki Watanabe, Takuya Inoue, Takumi Yamaura, Tomoko Suzuki, Miwako Saito, Katsunao Niitsuma, Kotaro Endo, Ikuro Oshibe, Nobutoshi Soeta, Takuro Saito, Hiroshi Hojo, Mitsuru Munakata and Hiroyuki Suzuki

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Oncotarget. 2018; 9:36012-36016. https://doi.org/10.18632/oncotarget.26325

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Abstract

Mitsunori Higuchi1, Masayuki Watanabe2, Takuya Inoue2, Takumi Yamaura2, Tomoko Suzuki3, Miwako Saito3, Katsunao Niitsuma3, Kotaro Endo4, Ikuro Oshibe4, Nobutoshi Soeta4, Takuro Saito4, Hiroshi Hojo5, Mitsuru Munakata3 and Hiroyuki Suzuki2

1Department of Thoracic Surgery, Aizu Medical Center, Fukushima Medical University, Tanisawa, Kawahigashi, Aizuwakamatsu 969-3492, Japan

2Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan

3Department of Infection and Pulmonary Medicine, Aizu Medical Center, Fukushima Medical University, Tanisawa, Kawahigashi, Aizuwakamatsu 969-3492, Japan

4Department of Surgery, Aizu Medical Center, Fukushima Medical University, Tanisawa, Kawahigashi, Aizuwakamatsu 969-3492, Japan

5Department of Pathology, Aizu Medical Center, Fukushima Medical University, Tanisawa, Kawahigashi, Aizuwakamatsu 969-3492, Japan

Correspondence to:

Mitsunori Higuchi, email: higuchi@fmu.ac.jp

Keywords: minute pulmonary meningothelial-like nodule; meningioma of central nervous system; immunohistochemistry; neurofibromatosis-2 gene; fluorescence in situ hybridization

Received: September 13, 2018     Accepted: October 25, 2018     Published: November 13, 2018

ABSTRACT

Introduction: Minute Pulmonary Meningothelial-like Nodules (MPMNs) are usually detected incidentally adjacent to lung cancer tissue. The pathogenesis is unknown. MPMNs reportedly share the status of neurofibromatosis (NF)-2 gene with meningiomas of the central nervous system.

Results: Immunohistochemical staining of two MPMNs revealed they were positive for epithelial membrane antigen (EMA), vimentin, CD56, and progesterone. We identified deletion of the NF-2 gene in two MPMNs and one CNS meningioma.

Conclusions: MPMN and CNS meningioma may develop via the same mechanism through NF-2 translocation. Further studies are required to elucidate the genetic similarities between these entities.

Methods: We used fluorescence in situ hybridization to explore the status of the NF-2 gene in MPMNs and compare it with that of CNS meningiomas. We used a commercially available locus-specific probe for the NF-2 region to analyze whole tissue sections of two MPMNs and two CNS meningiomas by fluorescence in situ hybridization.


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