Oncotarget

Research Papers:

The assessment of correlation and prognosis among 18F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients

Hayato Kaida _, Koichi Azuma, Akihiko Kawahara, Eiji Sadashima, Satoshi Hattori, Shinzo Takamori, Jun Akiba, Kiminori Fujimoto, Axel Rominger, Takamichi Murakami, Kazunari Ishii and Masatoshi Ishibashi

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Oncotarget. 2018; 9:31971-31984. https://doi.org/10.18632/oncotarget.25865

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Abstract

Hayato Kaida1, Koichi Azuma2, Akihiko Kawahara3, Eiji Sadashima4, Satoshi Hattori5, Shinzo Takamori6, Jun Akiba3, Kiminori Fujimoto7, Axel Rominger8, Takamichi Murakami9, Kazunari Ishii1 and Masatoshi Ishibashi10

1Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan

2Division of Respirology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan

3Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka, Japan

4Life Science, Saga-Ken Medical Centre Koseikan, Saga, Saga, Japan

5Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

6Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan

7Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan

8Department of Nuclear Medicine, Inselspital, Bern University Hospital, Bern, Switzerland

9Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

10Department of Radiology, Fukuoka Tokushukai Medical Center, Kasuga, Fukuoka, Japan

Correspondence to:

Hayato Kaida, email: kaida@med.kindai.ac.jp

Keywords: non-small cell lung cancer; volumetric parameters; Glut1; pStat1; pStat3

Received: June 09, 2018     Accepted: July 13, 2018     Published: August 10, 2018

ABSTRACT

Introduction: To assess the correlation among 18F-FDG uptake, Glut1, pStat1 and pStat3, and to investigate the relationship between the prognosis and 18F-FDG uptake and these molecular markers in surgically resected non-small cell lung cancer (NSCLC) patients.

Results: Knockdown of Glut1 led to a significant increase in pStat1 expression. Glut1 expression positively correlated with the SUVmax, SUVmean, and TLG significantly (P<0.001). pStat3 expression negatively correlated with all PET parameters significantly (P<0.001). pStat1 had positive weak correlations with the SUVmax and SUVmean. All PET parameters and Glut1 were significantly associated with DFS (P<0.05). TLG, MTV, Glut1 and pStat1 were significantly associated with OS (P<0.05).

Conclusion: pStat3 and Glut1 may be associated with 18F-FDG uptake mechanism. TLG, MTV, and Glut1 may be independent prognostic factors.

Methods: The SUVmax, SUVmean, MTV and TLG of primary lesions were calculated in 140 patients. The expressions of Glut1 and Stat pathway proteins in NSCLC cell lines were examined by immune blots. Excised tumor tissue was analyzed by immunohistochemistry. OS and DFS were evaluated by the Kaplan-Meier method. The difference in survival between subgroups was analyzed by log-rank test. The prognostic significance of clinicopathological, molecular and PET parameters was assessed by Cox proportional hazard regression analysis.


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