Oncotarget

Reviews:

Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment

Chuankuo Zhao, Mingshu Wang, Anchun Cheng _, Qiao Yang, Ying Wu, Dekang Zhu, Shun Chen, Mafeng Liu, XinXin Zhao, Renyong Jia, Kunfeng Sun and Xiaoyue Chen

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2018; 9:30704-30719. https://doi.org/10.18632/oncotarget.25694

Metrics: PDF 552 views  |   HTML 967 views  |   ?  


Abstract

Chuankuo Zhao1,2,3,*, Mingshu Wang1,2,3,*, Anchun Cheng1,2,3, Qiao Yang1,2,3, Ying Wu1,2,3, Dekang Zhu2,3, Shun Chen1,2,3, Mafeng Liu1,2,3, XinXin Zhao1,2,3, Renyong Jia1,2,3, Kunfeng Sun1,2,3 and Xiaoyue Chen2,3

1Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu City 611130, Sichuan, P.R. China

2Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, Chengdu City 611130, Sichuan, P.R. China

3Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu City 611130, Sichuan, P.R. China

*These authors have contributed equally to this study and should be listed as first authors

Correspondence to:

Anchun Cheng, email: chenganchun@vip.163.com

Mingshu Wang, email: mshwang@163.com

Keywords: alpha-herpesviruses; apoptosis; autophagy; necroptosis; cancer treatment

Received: November 06, 2017    Accepted: May 24, 2018    Published: July 17, 2018

ABSTRACT

Programed cell death is an antiviral mechanism by which the host limits viral replication and protects uninfected cells. Many viruses encode proteins resistant to programed cell death to escape the host immune defenses, which indicates that programed cell death is more favorable for the host immune defense. Alpha-herpesviruses are pathogens that widely affect the health of humans and animals in different communities worldwide. Alpha-herpesviruses can induce apoptosis, autophagy and necroptosis through different molecular mechanisms. This review concisely illustrates the different pathways of apoptosis, autophagy, and necroptosis induced by alpha-herpesviruses. These pathways influence viral infection and replication and are a potential avenue for cancer treatment. This review will increase our understanding of the role of programed cell death in the host immune defense and provides new possibilities for cancer treatment.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 25694