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Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER database analysis

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Oncotarget. 2018; 9:28897-28902. https://doi.org/10.18632/oncotarget.25622

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Dai Chihara _, Nathan H. Fowler, Yasuhiro Oki, Michelle A. Fanale, Loretta J. Nastoupil, Jason R. Westin, Luis E. Fayad, Sattva S. Neelapu and Chan Yoon Cheah

Abstract

Dai Chihara1, Nathan H. Fowler2, Yasuhiro Oki2, Michelle A. Fanale2, Loretta J. Nastoupil2, Jason R. Westin2, Luis E. Fayad2, Sattva S. Neelapu2 and Chan Yoon Cheah3,4,5

1Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA

2Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

3Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia

4Department of Haematology, Pathwest Laboratory Medicine WA, Nedlands, WA, Australia

5Medical School, University of Western Australia, Crawley, WA, Australia

Correspondence to:

Dai Chihara, email: dchihara-kob@umin.ac.jp

Keywords: primary central nervous system lymphoma; SEER; marginal zone lymphoma; follicular lymphoma; survival

Received: February 13, 2018    Accepted: May 31, 2018    Published: June 22, 2018

ABSTRACT

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extranodal presentation of lymphoma; however, the data for outcomes of patients with subtypes other than diffuse large B-cell lymphoma (DLBCL) are limited. Therefore, we analyzed overall survival (OS) of adult patients diagnosed with PCNSL by histologic subtype between 1998 and 2014 using the Surveillance, Epidemiology and End Results. A total of 4375 patients were identified. The median age of the patients was 64 years (range: 18-96). DLBCL was the most common histology (N=3,091), followed by follicular lymphoma (FL, N=83), peripheral T-cell lymphoma (PTCL, N=64), marginal zone lymphoma (MZL, N=63), Burkitt lymphoma (BL, N=27), small lymphocytic lymphoma (SLL, N=22), Hodgkin lymphoma (HL, N=13) and others (N=1,012). The 5-year OS rates were 30% in DLBCL, 66% in FL, 33% in PTCL, 79% in MZL, 42% in BL, 38% in SLL and 45% in HL. Radiation alone showed similar OS compared to no treatment in DLBCL, BL and PTCL, while radiation alone was associated with similar OS to chemotherapy or chemo-radiation in FL and MZL. The outcomes of patients with PCNSL are unfavorable; with the exception of FL and MZL which can potentially show prolonged survival with surgical resection or radiation monotherapy.


Impact of histologic subtypes and treatment modality among patients with primary central nervous system lymphoma: a SEER database analysis | Chihara | Oncotarget

INTRODUCTION

Primary central nervous system lymphoma (PCNSL) is a rare extranodal presentation that represents 1-2% of all non-Hodgkin lymphoma (NHL), however recent data indicate increasing incidence, particularly among the elderly [1, 2].

PCNSL is typically associated with an aggressive clinical course and poor outcome; however, there has been recent progress in treatment strategies. Current National Comprehensive Cancer Network (NCCN) guidelines for PCNSL recommend HD-MTX based induction regimen or whole brain radiation (WBRT) for patients who are not candidates for systemic chemotherapy [3]. The introduction of HD-MTX based regimen in the last two decades has resulted in substantial improvements in survival. Multiple trials have showed significant improvement in survival using HD-MTX based regimen compared to WBRT alone with a median OS of 30 to 60 months [48]. DeAngelis et al first showed that adding HD-MTX and high-dose cytarabine to WBRT significantly improved PFS compared to WBRT alone (median PFS: 10 months vs 41 month) [8], later confirmed in a multicenter study [5]. Although HD-MTX was initially introduced with WBRT, it became apparent among long-term survivors that delayed onset neurocognitive impairment (severe dementia and death) was problematic at conventional WBRT doses [9]. Therefore, chemotherapy-only approach or reduced dose WBRT for consolidation have been evaluated to reduce neurotoxicity. Also, high-dose chemotherapy with autologous stem cell transplant (auto-SCT) have resulted in improvements in outcomes in patients who responded to induction treatment [1012], and listed as an option for consolidation therapy in NCCN guideline. However, about 90% of PCNSL cases are diffuse large B-cell lymphoma (DLBCL); therefore all these data are mostly based on treatment outcome for patients with DLBCL and there are scarce data regarding outcomes of non-DLBCL histologic subtypes.

RESULTS

A total of 4375 patients with stage IE PCNSL were identified. The median age of the patients was 64 years (range, 18-96). DLBCL was the most common histologic subtype (N=3,091), followed by follicular lymphoma (FL, N=83), peripheral T-cell lymphoma (PTCL, N=64), marginal zone lymphoma (MZL, N=63), Burkitt lymphoma (BL, N=27), small lymphocytic lymphoma (SLL, N=22) and Hodgkin lymphoma (HL, N=13). In 1,012 patients (23%) the histologic subtype was recorded as “other” or “not otherwise specified” (Table 1).

Table 1: Patient characteristics

All

DLBCL

FL

MZL

*PTCL

SLL

BL

HL

N

4,375

3,091

83

63

64

22

27

13

Median age

(range)

64 (18-96)

65 |(18-96)

63 (30-86)

58 (23-92)

61 (18-83)

65 (41-81)

61 (30-77)

63 (38-80)

Male

2,336 (53)

1,628 (53)

42 (51)

16 (25)

36 (56)

9 (41)

18 (67)

8 (62)

Ethnicity

White

2,930 (67)

2,127 (69)

55 (66)

39 (62)

39 (61)

16 (72)

13 (48)

8 (62)

Black

350 (8)

181 (6)

5 (6)

9 (14)

8 (13)

1 (5)

2 (7)

1 (8)

Hispanic

616 (14)

421 (14)

16 (19)

8 (13)

12 (19)

3 (14)

6 (22)

4 (31)

Asian/Pacific

445 (10)

334 (11)

7 (8)

7 (11)

5 (8)

2 (9)

6 (22)

Others

34 (1)

11 (1)

Treatment

None

635 (15)

341 (11)

4 (5)

7 (11)

5 (8)

4 (18)

0 (0)

1 (8)

Surgery only

328 (8)

240 (8)

12 (15)

13 (21)

6 (9)

1 (5)

1 (4)

2 (15)

Radiation only

819 (19)

483 (16)

25 (30)

22 (35)

12 (19)

7 (32)

4 (15)

6 (46)

Chemotherapy only

1,754 (40)

1,392 (45)

15 (18)

12 (19)

28 (44)

5 (23)

17 (63)

3 (23)

Chemo-radiation

838 (19)

634 (21)

27 (33)

9 (14)

13 (20)

5 (23)

5 (19)

1 (8)

Abbreviation: DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MZL, marginal zone lymphoma; PTCL, peripheral T-cell lymphoma; SLL, small lymphocytic lymphoma; BL, Burkitt lymphoma; HL, Hodgkin lymphoma.

*PTCL includes peripheral T-cell lymphoma-not otherwise specified, angioimmuoblastic T-cell lymphoma, anaplastic large cell lymphoma.

Twenty-two percent of patients received neither radiation therapy (RT) nor chemotherapy, 19% of patients received RT alone, 40% of patients received chemotherapy alone and 19% of patients received combined modality therapy (CMT, chemo-radiation). Among patients who did not receive chemotherapy or radiation, 34% of patients underwent surgical resection. With a median follow up of 43 months (range: 1-202 months), 3,083 patients (70%) died and the median OS was 18 months (95%CI: 16-19). There was a significant difference in OS by histologic subtype (Figure 1): the 5-year OS rates were 30% (95%CI: 28-32%) in DLBCL, 66% (95%CI: 54-76%) in FL, 79% (95%CI: 64-88%) in MZL, 33% (95%CI: 20-45%) in PTCL, 42% (95%CI: 22-61%) in BL, 38% (95%CI: 18-57%) in SLL and 45% (95%CI: 17-71%) in HL. The differences in OS between each subtype are summarized in Supplementary Table 1. Multivariate analysis adjusted for age and treatment confirmed that patients with FL and MZL have significantly longer survival compared to patients with DLBCL (Table 2).

Overall survival of primary central nervous system lymphoma by histologic subtypes.

Figure 1: Overall survival of primary central nervous system lymphoma by histologic subtypes.

Table 2: Hazard ratio for OS compared to DLBCL

HR

95%CI

P-value

DLBCL

Reference

FL

0.32

0.23-0.46

<0.001

MZL

0.15

0.09-0.27

<0.001

PTCL

1.30

0.96-1.79

0.090

SLL

0.61

0.36-1.03

0.062

BL

0.86

0.52-1.40

0.540

HL

0.56

0.28-1.12

0.103

Abbreviation: HR, hazard ratio; CI, confidence interval; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MZL, marginal zone lymphoma; PTCL, peripheral T-cell lymphoma; SLL, small lymphocytic lymphoma; BL, Burkitt lymphoma; HL, Hodgkin lymphoma.

Response to therapy varied by histologic subtype. Among patients with aggressive histologic subtypes (DLBCL, BL and PTCL), radiation monotherapy was not associated with improvement in OS compared to no treatment. By contrast, among patients with indolent lymphomas (FL, MZL and SLL) radiation alone or resection without further therapy was associated with similar survival to chemotherapy or CMT (Figure 2).

Overall survival of primary central nervous system lymphoma by treatment strategies.

Figure 2: Overall survival of primary central nervous system lymphoma by treatment strategies.

Among patients with DLBCL, there was a significant improvement in survival by treatment era. A survival benefit was seen in both younger (age≤60 years) and older (age>60 years) patients (Figure 3A3C). There was no significant improvement in OS between 1998-2004 (N=853) and 2005-2009 (N=1,047) (median OS: 13 vs 14 months, p-value by log-rank test; all patients: P=0.075, younger: P=0.052, older: P=0.643) but there was a significant improvement in OS between 2005-2009 and 2010-2014 (N=1,191) (median OS: 14 vs 26 months, p-value by log-rank test; all patients: P<0.001, younger: P=0.018, older: P<0.001).

Figure 3:

Figure 3: (A) Trend of overall survival in diffuse large B-cell lymphoma type primary central nervous system lymphoma by year at diagnosis, (B) in younger patients, (C) in older patients.

DISCUSSION

PCNSL is a rare disease and there have been limited data available regarding survival outcomes of non-DLBCL PCNSL. Using registry data, we were able to analyze the incidence, treatment patterns and outcome of rare subtypes of PCNSL with a relatively large number of cases. Longer survival was seen in patients with MZL and FL compared to DLBCL.

In our study, the outcomes of patients with primary CNS T-cell lymphoma (TPCNSL) were comparable to DLBCL. In a multicenter international collaboration, Sjenkier et al described the clinical characteristics of 45 patients with TPCNSL [13]. The most common site of involvement was brain parenchyma (93%), and 19% of all patients also had cerebrospinal fluid involvement. With a median follow up of 22 months, the median progression-free survival and OS were 22 and 25 months respectively. This seems favorable compared to patients in our population-based cohort (median OS: 10 months). Unsurprisingly, the best outcomes were observed in patients with good performance status treated with MTX (median disease-specific survival 43 months). Treatment without HD-MTX was associated with inferior prognosis. MZL PCNSL was associated with the most favorable outcomes in our study. Recently, Ayanambakkam and colleagues systemically aggregated data from 69 patients with MZL PCNSL published as part of case series [14]. There was a female predominance (77%), concordant with our cohort (75%). Radiation ± surgery was the most common therapeutic approach (N=36), followed by CMT (N=16), surgery alone (N=11), while only 7 patients received chemotherapy ± surgery. After a median follow up of 23 months, only three relapses occurred with one death from sepsis, highlighting the indolent nature of disease.

Intensive approaches such as HD-MTX and auto-SCT have been shown to improve survival of patients with PCNSL; however, these approaches are only applicable to young and fit patients. Although our data showed improvement in survival outcomes for both younger and elderly patients, Mendez and colleagues recently showed that survival outcome of PCNSL is improving in young patients but not in elderly patients [15]. At the annual meeting of American Society of Hematology in 2016, multiple studies showed promising results by non-chemotherapy approaches, such as ibrutinib and lenalidomide, in PCNSL [1618]. In the phase I study evaluating single agent ibrutinib for PCNSL, ORR was seen in 77% of patients (10 of 13 patients) including 38% if CR (5 of 13 patients) [19]. The efficacy of these drugs are in line with the specific biology of disease [20, 21], and they are relatively well tolerated in elderly patients. However, new drugs can be associated with new toxicities, and thus requires careful investigation. In the study evaluated ibrutinib combined with chemotherapy, increased aspergillosis was observed in patients [22]. Further studies are warranted to evaluate the role of these agents in PCNSL.

Several limitations should be noted. As this study uses cancer registry data, there is no review of pathology and therefore the accuracy of diagnosis is unknown. In a prior study, Clarke et al showed the accuracy of diagnoses particularly in rare subtypes in SEER registry data is suboptimal [23]. However, in this study we evaluated lymphoma subtypes encountered relatively frequently by pathologists (at least in their nodal presentation). Further, SEER data does not contain detailed treatment information, thus we were unable to evaluate the impact of induction chemotherapy, salvage regimens and auto-SCT. Our reported survival outcomes according to treatment modality should be interpreted in view of these limitations.

In conclusion, histologic subtype is a major determinant of prognosis among patients with PCNSL. Patients with indolent subtypes such as FL and MZL have favorable outcomes irrespective of treatment modality. The prognosis of patients with PCNSL-DLBCL remains inferior to patients with nodal DLBCL. Novel therapies such as ibrutinib and lenalidomide appear both active and less toxic. These agents may have an important role to play, considering the incidence of PCNSL is increasing in elderly patients.

PATIENTS AND METHODS

The Surveillance, Epidemiology and End Results (SEER) 18 database, which currently covers approximately 27.8% of the US population, was used to evaluate overall survival (OS) of patients with PCNSL by different histologic subtypes in adult (≥18 years) patients diagnosed between 1998 and 2014. We only included stage I disease in this analysis but excluded primary vitreoretinal lymphoma. Overall survival (OS) was calculated from diagnosis to death from any cause using the Kaplan-Meier method. Differences in the survival function in different groups were analyzed using the log-rank test. Cox proportional hazards models were used to evaluate associations between patient characteristics and survival. All analyses were performed using STATA version 13.1 (StataCorp LP, College Station, TX), with significance set at the 5% level.

CONFLICTS OF INTEREST

Nothing to disclose.

FUNDING

None.

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