Oncotarget

Clinical Research Papers:

Trends and outcomes of women with synchronous endometrial and ovarian cancer

Koji Matsuo _, Hiroko Machida, Erin A. Blake, Laura L. Holman, Bobbie J. Rimel, Lynda D. Roman and Jason D. Wright

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Oncotarget. 2018; 9:28757-28771. https://doi.org/10.18632/oncotarget.25550

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Abstract

Koji Matsuo1,2, Hiroko Machida1, Erin A. Blake1, Laura L. Holman3, Bobbie J. Rimel4, Lynda D. Roman1,2 and Jason D. Wright5

1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA

2Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA

3Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

4Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

5Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA

Correspondence to:

Koji Matsuo, email: koji.matsuo@med.usc.edu

Keywords: endometrial cancer; ovarian cancer; trend; survival; synchronous

Received: December 21, 2017     Accepted: May 16, 2018     Published: June 19, 2018

ABSTRACT

This retrospective observational study examined trends, characteristics, and survival of women with synchronous endometrial and ovarian cancer (SEOC) in the Surveillance, Epidemiology, and End Results Program between 1973 and 2013. Among 235,454 women with primary endometrial cancer, synchronous ovarian cancer was seen in 4,082 (1.7%) women with the proportion being decreased from 2.0% to 1.6% between 1983 and 2013 (P=0.049); and the proportion of concurrent endometrioid tumors in the two cancer sites has increased from 24.2% to 49.9% among SEOC women (P<0.001). When compared to endometrial cancer without synchronous ovarian cancer, endometrioid histology in the two cancer sites was associated with improved cause-specific survival while non-endometrioid histology in the ovarian cancer was associated with decreased cause-specific survival (adjusted-P<0.01). Among 110,063 women with primary epithelial ovarian cancer, synchronous endometrial cancer was seen in 3,940 (3.6%) women with the proportion being increased from 2.2% to 4.4% between 1973 and 2013 (P<0.001); and the proportion of concurrent endometrioid tumors in the two cancer sites had increased from 24.3% to 50.2% among SEOC women (P<0.001). When compared to primary epithelial ovarian cancer without synchronous endometrial cancer, SEOC was associated with better cause-specific survival if ovarian cancer is endometrioid type or if endometrial cancer is endometrioid type (adjusted-P<0.001). Across the two cohorts, the proportion of SEOC reached to the peak in the late-40 years of age and then decreased significantly (P<0.001). In conclusion, our study suggests that synchronous ovarian cancer has decreased among endometrial cancer whereas synchronous endometrial cancer has increased among epithelial ovarian cancer.


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