miRNA signature of schwannomas: Possible role(s) of “tumor suppressor” miRNAs in benign tumors
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1Molecular Oncology Research Unit, Division of Oncology, Department of Pediatrics, Medical University of Vienna, Vienna 1090 Austria
2Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, 02129 USA
Keywords: miR-7, Tumor suppressor miRNAs, Benign tumors, Schwannomas, Neurofibromatosis 2 (NF2), Ack1
Received: March 30, 2011; Accepted: March 30, 2011; Published: March 30, 2011;
Okay Saydam, e-mail:
miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system. These benign tumors typically result from loss of the neurofibromatosis type 2 (NF2) tumor suppressor gene. We have recently carried out high-throughput miRNA expression profiling of human vestibular schwannomas using an array representing 407 known miRNAs in order to explore the role of miRNAs in the tumorigenesis of schwannomas. We found that miR-7 functions as a “tumor suppressor” by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1. Interestingly, in this study, we also observed that several previously described potential tumor suppressor miRNAs that are down-regulated in malignant tumors were up-regulated in schwannomas. Here we discuss the possibility that “tumor suppressor” miRNAs may play a role in the transition stage(s) of cancer from benign to malignant forms.
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