TP53  mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [ 18 F] fluorodeoxyglucose ( 18 F-FDG PET)

Geraldine H. Chang; Razelle Kurzrock; Lisa Tran; Maria Schwaederle; Carl K. Hoh

doi:10.18632/oncotarget.24508

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Research Papers:

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG PET)

Geraldine H. Chang, Razelle Kurzrock, Lisa Tran, Maria Schwaederle and Carl K. Hoh _

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Oncotarget. 2018; 9:14306-14310. https://doi.org/10.18632/oncotarget.24508

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Abstract

Geraldine H. Chang1, Razelle Kurzrock2, Lisa Tran2, Maria Schwaederle2 and Carl K. Hoh1

1Department of Radiology, Nuclear Medicine UC San Diego Health, San Diego, California, USA

2Center for Personalized Cancer Therapy, UCSD Moores Cancer Center, La Jolla, California, USA

Correspondence to:

Carl K. Hoh, email: [email protected]

Keywords: TP53; personalized cancer therapy; PET/CT; SUVmax

Received: August 31, 2017 Accepted: February 10, 2018 Epub: February 16, 2018 Published: March 06, 2018

ABSTRACT

Background: Our study explored the relationship between the molecular changes in cancer and the maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) with [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG).

Results: A higher SUVmax correlated with TP53 alterations, but not with histologic diagnosis or other gene/pathway mutations or copy number alterations. In data from breast, lung and colon cancer, patients with the highest SUVmax show more genomic anomalies compared to those with the lowest SUVmax (P < 0.005).

Conclusions: A higher SUVmax on ¹⁸F-FDG PET/CT is associated with TP53 tumor suppressor gene anomalies and the presence of more genomic anomalies. Since TP53 alterations and high SUVmax both correlate with a poor prognosis, the underlying mechanism/implications of this association merit further study.

Methods: Overall, 176 patients with diverse cancers had a tumor biopsy within 6 months after a PET/CT image for SUVmax measurement. The biopsy was interrogated by next generation sequencing (182 to 315 genes). TP53, EGFR, ALK, MYC, MET and FGF/FGFR genes and DNA repair, PI3K/Akt/mTOR (PAM), MEK, CYCLIN, and WNT pathway genes were analyzed.

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Research Papers:

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [18F] fluorodeoxyglucose (18F-FDG PET)

Abstract

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG PET)