Oncotarget

Research Papers: Pathology:

Peritumoral lymphoid cuff correlates well with lymph node enlargement in gastrointestinal schwannomas

Hyunsik Bae, Michael Van Vrancken, Tae Wook Kang, Ha Young Park, Jinah Chu, Hyung Kyu Park, Sang Yun Ha, Dongil Choi, Kyoung-Mee Kim _

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Oncotarget. 2018; 9:12591-12598. https://doi.org/10.18632/oncotarget.24476

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Abstract

Hyunsik Bae1,*, Michael Van Vrancken2,*, Tae Wook Kang3, Ha Young Park4, Jinah Chu1, Hyung Kyu Park1, Sang Yun Ha1, Dongil Choi3 and Kyoung-Mee Kim1

1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

2Department of Pathology, Christian Hospital, St. Louis, Missouri, USA

3Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

4Department of Pathology, Inje University Busan Paik Hospital, Inje University School of Medicine, Busan, Korea

*These authors contributed equally to this work

Correspondence to:

Kyoung-Mee Kim, email: kkmkys@skku.edu

Keywords: schwannoma; gastrointestinal tract; lymphoid cuff; lymphadenopathy; subepithelial tumor; Pathology

Received: November 01, 2017     Accepted: February 01, 2018     Published: February 09, 2018

ABSTRACT

Background/Aims: To determine the incidence of regional lymphadenopathy in gastrointestinal (GI) schwannoma and to evaluate the relationship between peritumoral lymphoid cuff and lymphadenopathy.

Methods: We queried 118 GI tract schwannomas and reviewed radiologic findings, intraoperative findings, and electronic medical records of all cases for enlarged regional lymph nodes.

Results: Location of tumors included 85 gastric (72%), 11 colonic (9.3%), 7 esophageal (5.9%), 3 pancreatic (2.5%), 1 hepatic (0.8%), and 11 mesenteric (9.3%). The size of the tumors ranged from 0.2 to 11 cm (mean 3.8 cm). Histologically, 70.3% showed a peritumoral lymphoid cuff ranging in thickness from 0.3 to 6 mm (mean 1.6 mm). The peritumoral lymphoid cuff was significantly more frequent in gastric schwannomas (78.8%) followed by colonic (72.7%), esophageal (57.1%) and rare in other locations (p = 0.001). Of the 106 cases for which clinical or radiologic data was available for, 76 cases (71.7%) showed regional lymphadenopathy. The presence of peritumoral lymphoid cuff showed significant correlation with regional lymphadenopathy (p < 0.001) and the size of enlarged lymph nodes (p = 0.002).

Conclusions: A peritumoral lymphoid cuff is frequently seen in GI tract schwannomas and correlates well with regional lymphadenopathy. However, in a significant subset (29.7%), a lymphoid cuff was not present warranting continued need for caution in the preoperative radiologic and postoperative pathologic diagnoses.


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