TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis

Sudhakar V. Nuti; Gil Mor; Peiyao Li; Gang Yin

doi:10.18632/oncotarget.2428

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis

Sudhakar V. Nuti, Gil Mor _, Peiyao Li and Gang Yin

PDF | HTML | How to cite

Oncotarget. 2014; 5:7260-7271. https://doi.org/10.18632/oncotarget.2428

Metrics: PDF 3355 views | HTML 3468 views | ?

Abstract

Sudhakar V. Nuti1, Gil Mor1, Peiyao Li2 and Gang Yin2

1 Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA

2 Department of Pathology, School of Basic Medicine, Central South University, Changsha, Hunan, China

Correspondence:

Gil Mor, email:

Gang Yin, email:

Keywords: ovarian cancer stem cells, EMT, MET, TWIST1, chemoresistance

Received: July 08, 2014 Accepted: September 02, 2014 Published: September 03, 2014

Abstract

The transcription factor TWIST1 is a highly evolutionally conserved basic Helix-Loop-Helix (bHLH) transcription factor that functions as a master regulator of gastrulation and mesodermal development. Although TWIST1 was initially associated with embryo development, an increasing number of studies have shown TWIST1 role in the regulation of tissue homeostasis, primarily as a regulator of inflammation. More recently, TWIST1 has been found to be involved in the process of tumor metastasis through the regulation of Epithelial Mesenchymal Transition (EMT). The objective of this review is to examine the normal functions of TWIST1 and its role in tumor development, with a particular focus on ovarian cancer. We discuss the potential role of TWIST1 in the context of ovarian cancer stem cells and its influence in the process of tumor formation.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 2428

Publication Alerts

Reviews:

TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis

Abstract