Long non-coding RNA  RAB11B-AS1  prevents osteosarcoma development and progression via its natural antisense transcript  RAB11B

Zhixu Chen; Zezheng Liu; Yang Yang; Zhaoyin Zhu; Ridong Liang; Bin Huang; Di Wu; Lei Yang; Hai Lu; Dadi Jin; Qingchu Li

doi:10.18632/oncotarget.24247

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Long non-coding RNA RAB11B-AS1 prevents osteosarcoma development and progression via its natural antisense transcript RAB11B

Zhixu Chen _, Zezheng Liu, Yang Yang, Zhaoyin Zhu, Ridong Liang, Bin Huang, Di Wu, Lei Yang, Hai Lu, Dadi Jin and Qingchu Li

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2018; 9:26770-26786. https://doi.org/10.18632/oncotarget.24247

Metrics: PDF 1618 views | HTML 1961 views | ?

Abstract

Zhixu Chen1,*, Zezheng Liu1,*, Yang Yang1, Zhaoyin Zhu1, Ridong Liang1, Bin Huang1, Di Wu2, Lei Yang2, Hai Lu1, Dadi Jin1 and Qingchu Li1

1Academy of Orthopedics, Guangdong Province, Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China

2The State Key Lab of Respiratory Disease, The Institute for Chemical Carcinogenesis, Collaborative Innovation Center for Environmental Toxicity, Guangzhou Medical University, Guangzhou 510182, China

*These authors contributed equally to this work

Correspondence to:

Qingchu Li, email: [email protected]

Keywords: lnc-RAB11B-AS1; osteosarcoma; RAB11B; proliferation; invasion

Received: January 25, 2017 Accepted: December 05, 2017 Epub: January 13, 2018 Published: June 01, 2018

ABSTRACT

Long non-coding RNAs (lncRNAs) have been shown to exert essential roles in development and progression of tumors. Here we discovered a novel lncRNA, RAB11B antisense RNA (RAB11B-AS1), which is markedly down-regulated in human osteosarcoma (OS) and associated with OS metastasis and poor prognosis. We find that reduction of RAB11B-AS1 significantly facilitates proliferation, migration and invasiveness and prevents apoptosis of OS cells and results in lower sensitivity to cisplatin in these cells. In contrast, up-regulation of RAB11B-AS1 suppresses the aggressive behaviors of OS cells. Mechanistically, down-regulation of RAB11B-AS1 elevates its sense-cognate gene RAB11B expression at both mRNA and protein levels. RAB11B-AS1 expression correlates negatively with RAB11B expression in OS tissues. Luciferase reporter assay illuminated that RAB11B-AS1 regulates RAB11B expression through antisense pairing. Most importantly, all the effects of RAB11B-AS1 were abrogated by RAB11B down-regulation. Thus our findings revealed that lnc-RAB11B-AS1 prevents osteosarcoma development and progression via inhibiting RAB11B expression, indicating lnc-RAB11B-AS1 as a potential therapeutic target for osteosarcoma.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24247

Publication Alerts

Research Papers:

Long non-coding RNA RAB11B-AS1 prevents osteosarcoma development and progression via its natural antisense transcript RAB11B

Abstract