Clinical Research Papers:
Prognostic role of neutrophil-to-lymphocyte ratio in patients with brain arteriovenous malformations
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Abstract
Sunfu Zhang1,*, Jing Zhang1,*, Qingqing Ren1,*, Min He1,*, Baoyin Shan1, Yunhui Zeng1, Zhiyong Liu1, Hao Liu1 and Jianguo Xu1
1Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, The First People’s Hospital of Yibin, Sichuan, People’s Republic of China
*These authors contributed equally to this work
Correspondence to:
Jianguo Xu, email: [email protected]
Keywords: brain arteriovenous malformations; cerebral hemorrhage; neutrophils; lymphocytes; prognosis.
Received: March 10, 2017 Accepted: December 05, 2017 Published: January 02, 2018
ABSTRACT
Purpose: This study was to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with brain arteriovenous malformations (AVMs).
Materials and Methods: Patients with AVMs were retrospectively identified. A hemogram from peripheral venous blood samples was taken within 24 hours of admission. The occurrences of death or major disability were noted at the end point of 6 months and the outcome was assessed with a modified Rankin Scale score.
Results: A total of 175 patients were enrolled. There were 97 (55%) patients in the ruptured AVMs group and 78 (45%) in the unruptured AVMs group. In patients with unruptured AVMs, NLR was an independent risk factor for poor outcome at 6 months (p = .036), but not a significant predictor with a ROC area of 0.638. Whereas, NLR was higher in the patients with poor outcome in ruptured AVMs group (p < .001). The area under the curve was .864 (P < .001), and an NLR of 8.88 was identified the best discriminating variable and the best predictive cutoff value.
Conclusions: NLR represented a reliable prognostic predictor for patients with ruptured AVMs. However, the NLR could not be a useful prognostic predictor for patients presented with unruptured AVMs.
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