Oncotarget

Research Papers:

MicroRNA-873 inhibits colorectal cancer metastasis by targeting ELK1 and STRN4

Chuannan Fan _, Biyu Lin, Zhengjie Huang, Dan Cui, Minyi Zhu, Zhenling Ma, Yunda Zhang, Fan Liu and Yingfu Liu

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Oncotarget. 2019; 10:4192-4204. https://doi.org/10.18632/oncotarget.24115

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Abstract

Chuannan Fan1,*, Biyu Lin1,*, Zhengjie Huang3,*, Dan Cui1,*, Minyi Zhu1, Zhenling Ma1, Yunda Zhang3, Fan Liu2 and Yingfu Liu2

1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Fujian Sheng, People’s Republic of China

2Medical College of Xiamen University, Department of Basic Medical Sciences, Medical College, Xiamen University, Fujian Sheng, People’s Republic of China

3Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, Fujian Sheng, People’s Republic of China

*These authors contributed equally to this work

Correspondence to:

Yingfu Liu, email: liuyingfu@126.com

Fan Liu, email: liufan@xmu.edu.cn

Keywords: colorectal cancer; miR-873; ELK1; STRN4; metastasis

Received: July 03, 2017     Accepted: December 01, 2017     Epub: January 02, 2018     Published: June 25, 2019

ABSTRACT

MicroRNAs (miRNAs) are a group of small non-coding RNAs that directly bind to the 3ʹ-untranslated-region (3ʹUTR) of mRNA, thereby blocking gene expression post-transcriptionally. Accumulating evidence prove that microRNA-873 (miR-873) functions as a promoter or suppressor in various cancers, while whether it affects the progression of colorectal cancer (CRC) is yet unknown. Here we found that miR-873 was downregulated in human CRC clinical samples, mouse CRC specimens and cell lines with high metastatic potential. We also demonstrated that low miR-873 expression was closely associated with poor prognosis of CRC. Overexpressing miR-873 suppressed proliferation and metastasis of CRC cells both in vitro and in vivo, while inhibiting miR-873 expression promoted the proliferation, migration and invasion in vitro. Moreover, miR-873 exerted its function by perturbing the ERK-CyclinD1 pathway and the epithelial-mesenchymal transition (EMT) process. Furthermore, we revealed that miR-873 acted as a tumor-suppressive microRNA by directly binding to the 3ʹUTRs of ELK1 and STRN4 and suppressed their expression. Our study uncovered an inhibitory role of miR-873 in CRC progression and might provide a promising marker for CRC diagnosis and prognosis.


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