Cryoablation inhibition of distant untreated tumors (abscopal effect) is immune mediated
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Xueling Yang1,2,3,4, Yongfei Guo5, Zhi Guo1,2,3,4, Tongguo Si1,2,3,4, Wenge Xing1,2,3,4, Wenwen Yu2,3,4,6 and Yan Wang1,2,3,4
1Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
2National Clinical Research Center of Cancer, Tianjin 300060, China
3Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
4Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
5Department of Interventional Radiology, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 100020, China
6Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
Zhi Guo, email: firstname.lastname@example.org
Keywords: cryoablation; abscopal effect; immune response
Received: August 14, 2017 Accepted: January 03, 2018 Epub: January 10, 2018 Published: June 25, 2019
Cryoablation is moderately effective against prostate cancer. Of note, the off-target or enlarged therapeutic effect after cryoablation is reported in routine clinical practice. To uncover it, we constructed a bilateral inguinal transplantation model of prostate cancer. All the mice were randomly subdivided into three groups: Group A (Control group), Group B (Surgery group), and Group C (Cryoablation group). All the procedures in three groups were conducted only for tumors in the target region (right groin). The tumors in untargeted region (left groin) received no treatment. We measured the growth of untargeted tumors and lung metastasis rate, and then explored the changes in a series of immune cells and danger signals. First, our results revealed the protective effect of cryoablation treatment against the abscopal tumor. The possible mechanism was mediated by an increase in the number of CD4+ T cells, CD8+ T cells, ratio T helper 1 (Th1)/Th2, the killing activity of cytotoxic T lymphocytes and NK cells. Hsp70 may be involved in the modulation of the immune response. The combination of weakened Ki67 activity and activated immune response delayed spectator tumor growth, decreased the pulmonary metastasis rate, and prolonged animal survival, with an inducible abscopal effect.
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