Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 2: ADCmin
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Alexey Surov1,*, Hans Jonas Meyer1,* and Andreas Wienke2,*
1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany
2Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
*These authors contributed equally to this work
Alexey Surov, email: Alexey.Surov@medizin.uni-leipzig.de
Keywords: diffusion weighted imaging; ADC; KI 67
Received: July 06, 2017 Accepted: November 13, 2017 Published: January 04, 2018
The purpose of this part of the meta-analysis was to summarize data regarding associations between minimum apparent diffusion coefficient (ADCmin) and KI 67 in different tumors.
MEDLINE library was screened for associations between ADCmin and KI 67 in different tumors up to April 2017. Overall, 23 studies with 944 patients were identified. Associations between ADC and KI 67 were analyzed by Spearman's correlation coefficient.
The pooled correlation coefficient between ADCmin and KI 67 for all included tumors was ρ = -0.47. In detail, the correlation coefficients for separate tumors were as follows: cerebral lymphoma: ρ = –0.61 (95% CI = [–0.82; –0.41]); cervical cancer: ρ = –0.56 (95% CI = [–0.68;–0.43]); pituitary adenoma: ρ = –0.55 (95% CI = [–1.31; 0.22]); glioma: ρ = –0.40 (95% CI = [–0.55; –0.24]); breast cancer: ρ = –0.37 (95% CI = [–0.74; –0.01]); meningioma, ρ = –0.15 (95% CI = [–0.38; 0.07]).
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