Coptisine, an alkaloid from Rhizoma Coptidis, inhibits  Helicobacter pylori  urease activity by targeting its active site and maturation process

Cailan Li; Cailan Li; Ping Huang; Ping Huang; Kambo Wong; Kambo Wong; Yifei Xu; Yifei Xu; Lihua Tan; Lihua Tan; Hanbin Chen; Hanbin Chen; Qiang Lu; Qiang Lu; Chaodan Luo; Chaodan Luo; Chunlai Tam; Chunlai Tam; Lixiang Zhu; Lixiang Zhu; Ziren Su; Ziren Su; Jianhui Xie; Jianhui Xie

doi:10.18632/oncotarget.24002

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This paper was originally published in Oncotarget Advance Online Publications on 01/08/2018.
In compliance with Oncotarget's withdrawal policy, the paper was withdrawn in its entirety. It will not appear in Oncotarget internal or any external indexes or archives.

Research Papers:

Coptisine, an alkaloid from Rhizoma Coptidis, inhibits Helicobacter pylori urease activity by targeting its active site and maturation process

Cailan Li, Cailan Li, Ping Huang, Ping Huang, Kambo Wong, Kambo Wong, Yifei Xu, Yifei Xu, Lihua Tan, Lihua Tan, Hanbin Chen, Hanbin Chen, Qiang Lu, Qiang Lu, Chaodan Luo, Chaodan Luo, Chunlai Tam, Chunlai Tam, Lixiang Zhu, Lixiang Zhu, Ziren Su _, Ziren Su, Jianhui Xie and Jianhui Xie _

Cailan Li1,*, Ping Huang2,*, Kambo Wong3, Yifei Xu2, Lihua Tan1, Hanbin Chen4, Qiang Lu5, Chaodan Luo1, Chunlai Tam3, Lixiang Zhu2, Ziren Su1,6 and Jianhui Xie7

1 Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China

2 School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China

3 School of Life Sciences, Center for Protein Science and Crystallography, The Chinese University of Hong Kong, Hong Kong, P. R. China

4 The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China

5 Key Laboratory of Ministry of Education, Research Center of Chinese Herbal Resources and Engineering, Guangzhou University of Chinese Medicine, Guangzhou, P.R China

6 Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, P. R. China

7 Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China

* These authors have contributed equally to this work

Correspondence to:

Ziren Su, email: [email protected]

Jianhui Xie, email: [email protected]

Keywords: coptisine; Helicobacter pylori urease; sulfhydryl group; nickel ion; UreG

Received: May 18, 2017 Accepted: January 01, 2018 Epub: January 08, 2018

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PII: 24002

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Research Papers:

Coptisine, an alkaloid from Rhizoma Coptidis, inhibits Helicobacter pylori urease activity by targeting its active site and maturation process