Research Papers: Gerotarget (Focus on Aging):
Possible mechanism underlying the association between height and vascular remodeling in elderly Japanese men
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Yuji Shimizu1,2, Shimpei Sato1, Jun Koyamatsu3, Hirotomo Yamanashi3, Mako Nagayoshi1, Koichiro Kadota1, Shin-Ya Kawashiri1 and Takahiro Maeda1,3
1Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
2Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan
3Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
Yuji Shimizu, email: firstname.lastname@example.org
Keywords: platelets; height; vascular remodeling; CIMT; CD34-positive cell; Gerotarget
Received: September 29, 2017 Accepted: October 30, 2017 Published: December 23, 2017
Height is reported to be inversely associated with cardiovascular disease. And platelets play an important role in vascular remodeling by supporting CD34-positive cells. To clarify the association between height and platelet, we conducted a cross-sectional study of 219 elderly Japanese men. Since hemoglobin concentration is influenced by vascular remodeling activity, an analysis stratified by hemoglobin level was performed. An inverse association was seen between height and platelet count in subjects with a high hemoglobin concentration (≥ 14.5 g/dL), but not in subjects with a low hemoglobin concentration (< 14.5 g/dL). The standardized parameter estimates (β) were β = −0.22, p = 0.019 for subjects with high hemoglobin, and β = −0.01, p = 0.931 for subjects with low hemoglobin. We also found a positive association between platelets and carotid intima media thickness (CIMT) and circulating CD34-positive cells in subjects with high hemoglobin (partial correlation coefficient (r) = 0.21, p = 0.037 and r = 0.40, p =< 0.001), but not in subjects with low hemoglobin (r = 0.04, p = 0.710 and r = 0.06, p = 0.544). In subjects with a high hemoglobin concentration, platelets were inversely associated with height, and positively associated with CIMT and circulating CD34-positive cells. These results indicate that subjects with a short stature activate vascular remodeling to a much greater extent than subjects with a tall stature.
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