Oncotarget

Research Papers:

Variants in the APOB gene was associated with Ischemic Stroke susceptibility in Chinese Han male population

Feng Zhou, Tie Guo, Lv Zhou, Yanhui Zhou and Dan Yu _

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Oncotarget. 2018; 9:2249-2254. https://doi.org/10.18632/oncotarget.23369

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Abstract

Feng Zhou1, Tie Guo1, Lv Zhou1, Yanhui Zhou1 and Dan Yu1

1Department of Neurology, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, Haikou 570208, Hainan, China

Correspondence to:

Dan Yu, email: danjasaon@qq.com

Yanhui Zhou, email: yhzhou81@yeah.net

Keywords: Ischemic Stroke; APOB; gene polymorphism; massARRAY

Received: June 20, 2017     Accepted: September 05, 2017     Published: December 18, 2017

ABSTRACT

Background: Stroke is an extremely complicated disease caused by multiple factors. Epidemiological studies have shown that genetic factors contribute to the pathogenesis of stroke. There is still little research on the effect of ApoB gene on stroke in Chinese Han population. The purpose of our research was to explore the effect of ApoB gene polymorphism on the genetic susceptibility to Ischemic Stroke in Chinese Han male population.

Materials and methods: 7 polymorphisms in ApoB gene were selected and genotyped using Sequenom MassARRAY in 325 ischemic stroke male patients and 399 healthy male controls in Chinese Han population. The association between ApoB gene and genetic susceptibility to Ischemic Stroke was performed by the χ2 test, genetic model analysis and haplotype analysis.

Results: In the allele model, ApoB rs1042034 “T” allele and rs673548 “G” allele increased the risk of the Ischemic Stroke (rs1042034: OR=1.29, 95%CI: 1.02-1.63, p=0.030; rs673548: OR=1.28, 95%CI: 1.02-1.62, p=0.034). Logistic regression analysis found that ApoB rs1042034 and rs673548 increased the risk of Ischemic Stroke in the log-additive model, the odds of having Ischemic Stroke would be 1.28-fold and 1.27-fold with the variant allele, respectively. We also found that the risk of individuals carrying the ApoB rs693 “AA-AG” genotype had Ischemic Stroke risk of 1.52-fold of carrying “GG” genotype in the dominant model. The haplotype analysis shown that “TAG” haplotype raised the risk of Ischemic Stroke (OR=1.52, 95%CI: 1.02-2.27, p=0.0042).

Conclusion: The polymorphisms of the ApoB gene may affect Ischemic Stroke occurrence.


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