Oncotarget

Research Papers:

Elevated level of D-dimer increases the risk of stroke

Jing Zhang, Yanlin Song, Baoyin Shan, Min He, Qingqing Ren, Yunhui Zeng, Zhiyong Liu, Hao Liu and Jianguo Xu _

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Oncotarget. 2018; 9:2208-2219. https://doi.org/10.18632/oncotarget.23367

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Abstract

Jing Zhang1,*, Yanlin Song2,*, Baoyin Shan1,*, Min He1, Qingqing Ren1, Yunhui Zeng1, Zhiyong Liu1, Hao Liu1 and Jianguo Xu1

1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China

2West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China

*These authors have contributed equally to this work

Correspondence to:

Jianguo Xu, email: jianguo_1229@126.com

Keywords: D-dimer; stroke; risk factor

Received: August 05, 2017    Accepted: September 20, 2017    Published: December 18, 2017

ABSTRACT

The aim of this study was to systematically evaluate the association between D-dimer level and the risk of stroke through performing a meta-analysis. PubMed, Web of Science, EMBASE and Cochrane Library were searched for potentially eligible literature. Prospective observational studies or case-control studies were included. The study characteristics and relevant data were extracted. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the association between D-dimer level and the risk of stroke. Seven prospective studies with 22,207 patients and three case-control studies with 2,248 patients were included. For the prospective studies, the pooled HRs of higher D-dimer level for all types of stroke, ischemic stroke and hemorrhagic stroke were 1.55 (95% CI, 1.28-1.87), 1.62 (95% CI, 1.18-2.22) and 1.30 (95% CI, 0.63-2.68), respectively. The pooled HRs per SD increase in log D-dimer for all types of stroke, ischemic stroke and hemorrhagic stroke were 1.16 (95% CI, 1.06-1.26), 1.11 (95% CI, 1.03-1.21) and 1.11 (95% CI, 0.95-1.30), respectively. For the case-control studies, the pooled OR of higher D-dimer level for acute ischemic stroke was 2.06 (95% CI, 1.08-3.96). No significant publication bias was found in the meta-analysis. In conclusion, our results suggested that higher D-dimer level was associated with higher risk of stroke, especially ischemic stroke.


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