The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

Jiabei Wang; Dalong Yin; Changming Xie; Tongsen Zheng; Yingjian Liang; Xuehui Hong; Zhaoyang Lu; Xuan Song; Ruipeng Song; Haiyan Yang; Boshi Sun; Nishant Bhatta; Xianzhi Meng; Shangha Pan; Hongchi Jiang; Lianxin Liu

doi:10.18632/oncotarget.2328

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

Jiabei Wang, Dalong Yin, Changming Xie, Tongsen Zheng, Yingjian Liang, Xuehui Hong, Zhaoyang Lu, Xuan Song, Ruipeng Song, Haiyan Yang, Boshi Sun, Nishant Bhatta, Xianzhi Meng, Shangha Pan, Hongchi Jiang and Lianxin Liu _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2014; 5:8478-8491. https://doi.org/10.18632/oncotarget.2328

Metrics: PDF 2668 views | HTML 3932 views | ?

Abstract

Jiabei Wang1,*, Dalong Yin1,*, Changming Xie1,*, Tongsen Zheng1,*, Yingjian Liang 1, Xuehui Hong1, Zhaoyang Lu1, Xuan Song1, Ruipeng Song1, Haiyan Yang1, Boshi Sun1, Nishant Bhatta1, Xianzhi Meng1, Shangha Pan1, Hongchi Jiang1 and Lianxin Liu1,2

1 Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang Province, China

2 Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin, China

* These authors contributed equally to this work

Correspondence:

Lianxin Liu, email:

Keywords: Dp44mT; NDRG2; hepatocellular carcinoma; metastasis; STAT3

Received: June 09, 2014 Accepted: August 07, 2014 Published: August 08, 2014

Abstract

Here we showed that hepatocellular carcinoma (HCC) cell lines with high metastatic potential had low levels of NDRG2. The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having high metastatic potential. Also Dp44mT attenuated the TGF-β1-induced EMT in HCC having low metastatic potential. In agreement, silencing endogenous NDRG2 with shNDRG2 in HCC cells attenuated the effect of Dp44mT. We showed that the NDRG2/gp130/STAT3 pathway can mediate Dp44mT effects. In agreement, we found that a combination of NDRG2 expression and p-STAT3 levels is a strong predictor of prognosis in HCC patients. We suggest that up-regulation of NDRG2 by Dp44mT is a promising therapeutic approach in HCC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 2328

Publication Alerts

Research Papers:

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

Abstract