SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer

Tian Tian; Ran Qiu; Xia Qiu

doi:10.18632/oncotarget.23255

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Research Papers:

SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer

Tian Tian _, Ran Qiu and Xia Qiu

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Oncotarget. 2018; 9:2128-2139. https://doi.org/10.18632/oncotarget.23255

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Abstract

Tian Tian1, Ran Qiu2 and Xia Qiu3

1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

2Wuhan Institute of Bioengineering, Wuhan, People’s Republic of China

3Department of Medicine, Shangqiu Medical School, Shangqiu, People’s Republic of China

Correspondence to:

Tian Tian, email: [email protected]

Keywords: SNHG1; miR-145; colorectal cancer; ncRNA; lncRNA

Received: August 10, 2017 Accepted: December 05, 2017 Published: December 14, 2017

ABSTRACT

ncRNAs are important regulatory molecules and involve in many physiological cellular processes. Small nucleolar RNA host gene 1 (SNHG1) is a host to 8 snoRNAs and is located in 11q12.3 region of the chromosome. It has been reported to be involved in several cancers. However, the role of SNHG1 in the tumorigenesis of colorectal cancer is still unknown. In this study, SNHG1 was upregulated in colorectal cancers, and SNHG1 expression was correlated with advanced colorectal cancer stage and tumor recurrence. We found that SNHG1 promoted cell proliferation by acting as a sponge of miR-145, a well known tumor suppressor of colorectal cancer. Furthermore, the survival analysis indicated that colorectal cancer patients with higher expression of SNHG1 had a worse prognosis. These findings suggested that SNHG1 may act as a potential therapeutic target for the treatment of colorectal cancer.

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Research Papers:

SNHG1 promotes cell proliferation by acting as a sponge of miR-145 in colorectal cancer

Abstract