Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis

Luying Huang; Yi Wang; Hua Liu; Jianhua Huang

doi:10.18632/oncotarget.23246

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers: Gerotarget (Focus on Aging):

Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis

Luying Huang, Yi Wang, Hua Liu and Jianhua Huang _

PDF | HTML | How to cite

Oncotarget. 2018; 9:8241-8252. https://doi.org/10.18632/oncotarget.23246

Metrics: PDF 2436 views | HTML 1975 views | ?

Abstract

Luying Huang1,4,*, Yi Wang1,2,*, Hua Liu3 and Jianhua Huang1

1First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China

2School of Pharmaceutical Science, Jinzhou Medical University, Jinzhou, China

3Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China

4Graduated School of Jinzhou Medical University, Jinzhou, China

*These authors contributed equally to this work

Correspondence to:

Jianhua Huang, email: [email protected]

Hua Liu, email: [email protected]

Keywords: high molecular hyaluronan; wound healing; angiogenesis; aging

Received: September 26, 2016 Accepted: December 09, 2017 Published: December 14, 2017

ABSTRACT

Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healing in old rats by local injection. We found that HMW-HA significantly increases proliferation, migration and tube formation in endothelial cells, and protects endothelial cells against apoptosis. Local injection of HMW-HA promotes wound healing by increasing angiogenesis in old rats. HMW-HA increases the phosphorylation of Src, ERK and AKT, leading to increased angiogenesis, suggesting that local injection of HMW-HA promotes wound healing in elderly patients.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 23246

Publication Alerts

Research Papers: Gerotarget (Focus on Aging):

Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis

Abstract