Oncotarget

Research Papers: Gerotarget (Focus on Aging):

Local injection of high-molecular hyaluronan promotes wound healing in old rats by increasing angiogenesis

Luying Huang, Yi Wang, Hua Liu, Jianhua Huang _

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Oncotarget. 2018; 9:8241-8252. https://doi.org/10.18632/oncotarget.23246

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Abstract

Luying Huang1,4,*, Yi Wang1,2,*, Hua Liu3 and Jianhua Huang1

1First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China

2School of Pharmaceutical Science, Jinzhou Medical University, Jinzhou, China

3Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China

4Graduated School of Jinzhou Medical University, Jinzhou, China

*These authors contributed equally to this work

Correspondence to:

Jianhua Huang, email: hjhuadr@163.com

Hua Liu, email: lh5095153@163.com

Keywords: high molecular hyaluronan; wound healing; angiogenesis; aging

Received: September 26, 2016     Accepted: December 09, 2017     Published: December 14, 2017

ABSTRACT

Impaired angiogenesis contributes to delayed wound healing in aging. Hyaluronan (HA) has a close relationship with angiogenesis and wound healing. However, HA content decreases with age. In this study, we used high molecular weight HA (HMW-HA) (1650 kDa), and investigated its effects on wound healing in old rats by local injection. We found that HMW-HA significantly increases proliferation, migration and tube formation in endothelial cells, and protects endothelial cells against apoptosis. Local injection of HMW-HA promotes wound healing by increasing angiogenesis in old rats. HMW-HA increases the phosphorylation of Src, ERK and AKT, leading to increased angiogenesis, suggesting that local injection of HMW-HA promotes wound healing in elderly patients.


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